Importance of determining apolipoproteins B and A-1 in clinical practice

Czech version

Authors: H. Vaverková
Published in: Kardiol Rev Int Med 2012, 14(3): 153-156
Category:

Overview

Apolipoproteins (Apo) are protein components of lipoprotein macromolecules. They fulfil various functions that can affect the destiny of lipoprotein particles, thus influencing the atherogenesis process. In terms of clinical practice, only the determination of ApoB has been of importance so far: ApoB is an indicator of the total number of atherogenic particles as well as a good surrogate marker of the number of small dense LDL (sdLDL). According to the ESC/EAS 2011 guidelines, ApoB should be considered an alternative risk marker in patients with combined hyperlipidemia, metabolic syndrome, diabetes and chronic kidney disease. In these patients, ApoB is also a secondary target indicator of treatment efficacy. Neither ApoA-1 nor the ApoB/ApoA-1 ratio is suitable for assessing treatment efficacy.

Keywords:
apolipoprotein B – apolipoprotein A-1 – LDL-cholesterol – cardiovascular risk – guidelines – lipid-lowering therapy

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