Axis of athero-evil: liver – vessel – heart

Czech version

Authors: Jan Piťha ^1,2
Authors‘ workplace: Kardiocentrum, Klinika kardiologie IKEM, Praha ¹; Centrum experimentální medicíny, Laboratoř pro výzkum aterosklerózy IKEM, Praha ²
Published in: AtheroRev 2021; 6(3): 139-142
Category: Reviews

Overview

Risk factors for cardiovascular disease are clearly defined. These include smoking, dyslipidemia, hypertension and diabetes mellitus. The detection and impact of these risk factors is essential for the prevention of ischemic heart disease in particular, but also of non-ischemic cardiovascular diseases, such as heart failure with a preserved ejection fraction caused mainly by hypertension. Other, detectable risk factors, which may even be at the very beginning of these disorders, may also play an important role in vascular and cardiac pathological processes. In the latter group, there is also included liver (dys)funciton. The presence of liver steatosis or even of higher stages of liver disease is not only risk factor for liver cirrhosis and failure but also for cardiovascular disease. Based on studies focused on even moderate liver dysfunction as a possible cause of cardiovascular diseases, attention should shift also on the prevention of these diseases in the stage of early liver disease. Convincing data in terms of specific treatment for signs of liver disease are still not available, but this situation could change in the future and it is wise to be prepared for it.

Keywords:

diagnosis – management – cardiovascular disease – liver steatosis

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