Hypertriglyceridemia – today and tomorrow

Czech version

Authors: Martin Šatný; Michal Vrablík
Authors‘ workplace: Centrum preventivní kardiologie, III. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a VFN v Praze
Published in: AtheroRev 2020; 5(3): 163-167
Category: Reviews

Overview

Hypertriglyceridemia (HTG) is the marker of elevated levels of highly atherogenic, triglyceride (TG) rich, i.e. remnant particles. These play a major role not only in the development of atherosclerotic vascular lesions, but also in serious gastrointestinal complications: acute pancreatitis. Influencing the level of TG, or remnant particles, is considered to be one of the modalities for reducing residual cardiovascular risk. Therapeutic intervention is based on regimen measures (a diet and regular physical activity), which is supplemented by pharmacotherapy in indicated cases. Statins remain the drug of choice also in HTG treatment; optionally they are combined with fibrates or omega-3 fatty acids. At present, we have (in part within studies) new therapeutic possibilities available for influencing HTG, using, for example, antisense oligonucleotides or targeted antibodies.

Keywords:

statins – hypertriglyceridemia – remnant particles

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