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proLékaře.cz / Journals / Athero Review / 2018 - 3

Statins, brain and cholesterol: is it going together?

Czech version

Authors: Vladimír Soška 1,2
Authors‘ workplace: Oddělení klinické biochemie, ICRC – oddělení kardiovaskulárních chorob FN u sv. Anny v Brně 1;  Katedra laboratorních metod LF MU Brno a II. interní klinika LF MU a FN u sv. Anny v Brně 2
Published in: AtheroRev 2018; 3(3): 169-172
Category: Reviews

Overview

Statins are among the primary drugs for the prevention of atherosclerotic cardiovascular disease. Compliance to long-term statin treatments is unsatisfactory, and one of the reasons are some rumors about their side effects, including concerns about brain damage, both directly from statins and due to very low blood LDL-cholesterol levels. However, blood cholesterol levels do not affect the brain‘s cholesterol supply because brain has its own regulatory mechanisms that control its endogenous synthesis, transport, degradation and excretion. Regarding the side effects of statins on the brain, it has not been demonstrated that statin administration has a negative effect on brain function, and some newer meta-analyzes confirm the positive effects of statins in some neurological diseases.

Key words:

brain, cholesterol, statins

Received: 4. 9. 2018

Accepted: 26. 9. 2018

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