Septic shock in fatal pneumonia caused by Staphylococcus aureus: The significance of producing Pantone-Valentine leukocidine – case report
Authors:
Beneš Jiří 1; Myslivec Ondřej 2; Laštíková Jarmila 3; Gabrielová Alice 4; Petráš Petr 5; Pantůček Roman 6
Authors‘ workplace:
Klinika infekčních nemocí 3. LF UK, FN Na Bulovce, Praha
1; 1. interní oddělení FN Na Bulovce, Praha
2; Patologicko-anatomické oddělení FN Na Bulovce, Praha
3; Oddělení klinické mikrobiologie FN Na Bulovce, Praha
4; Národní referenční laboratoř pro stafylokoky, Státní zdravotní ústav, Praha
5; Ústav experimentální biologie, Přírodovědecká fakulta MU, Brno
6
Published in:
Anest. intenziv. Med., 21, 2010, č. 6, s. 337-341
Category:
Intensive Care Medicine - Original Paper
Overview
Necrotizing pneumonia caused by Staphylococcus aureus producing Pantone-Valentine leukocidin (PVL) is a rare but life-threatening disease. Early diagnosis of staphylococcal etiology is necessary for successful treatment. Linezolid is the first choice antibiotic that should be preferred to beta-lactams and vancomycin in this indication.
We report a case of 29-year-old man who was admitted for severe septic shock and incipient pneumonia and died 8 hours after admission despite intensive care. PVL-producing Staphylococcus aureus was isolated from the blood cultures.
Keywords:
sepsis – pneumonia – Staphylococcus aureus – Pantone-Valentine leukocidin
Sources
1. Dellinger, R. P., Levy, M. M., Carlet, J. M. et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med., 2008, 36, 1, p. 296–327.
2. Kolek, V. et al. Standard léčebného plánu: Diagnostika a léčba komunitně získané pneumonie dospělých. Doporučený postup České pneumologické a ftizeologické společnosti. Dostupné na www: http://www.pneumologie. cz/odborne/doc/Pneumonie%20standard%20RESP2%202007.pdf
3. Petráš, P., Ježek, P., Machová, I. et al. Další smrtelný případ pneumonie vyvolaný kmenem Staphylococus aureus s produkcí Pantonova-Valentinova leukocidinu. Zprávy EM (SZÚ Praha), 2008, 18, 1, p. 15–17.
4. Ježek, P., Bílina, P., Petráš, P. Fatální pneumonie vyvolaná kmenem Staphylococcus aureus produkujícím Pantonův-Valentinův leukocidin. Antiinfect News, 2010, 1, 1, p. 10–12.
5. Heinige, P., Dedek, V., Fajt, M. et al. Nekrotizující pneumonie kojence s fatálním průběhem, způsobená PVL pozitivním zlatým stafylokokem. Pediatr. Prax., 2009, 10, 5, p. 326–328.
6. Petráš, P., Rumlerová, M., Machová, I. et al. Letální abscedující pneumonie vyvolaná kmenem Staphylococcus aureus oxacilin rezistentním s produkcí Pantonova-Valentinova leukocidinu. Prakt. Lék., 2007, 88, 4, p. 236–239.
7. Que, Y. A., Morellion, P. Staphylococcus aureus (including staphylococcal toxic shock). In Mandell, G. L., Bennett, J. E., Dolin, R. (eds) Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone, 2009, p. 2543–2578.
8. Rojo, P., Barrios, M., Palacios, A. et al. Community-associated Staphylococcus aureus infections in children. Expert Rev. Anti. Infect. Ther., 2010, 8, 5, p. 541–554.
9. Stein, G. E., Wells, E. M. The importance of tissue penetration in archieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid. Curr. Med. Res. Opin., 2010, 26, 3, p. 571–588.
10. Yanagihara, K., Kihara, R., Araki, N. et al. Efficacy of linezolid against Panton-Valentine leucocidin (PVL-positive methicillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection. Int. J. Antimicrob. Agents, 2009, 34, 5, p. 477–481.
11. Rouzic, N., Janvier, F., Libert, N. et al. Prompt and succesful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leucocidin genes. J. Clin. Microbiol., 2010, 48, 5, p. 1952–1955.
12. Singh, S. R., Bacon, A. E., Young, D. C., Couch, K. A. In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother., 2009, 53, 10, p. 4495–4497.
13. Zyvoxid. Souhrn informací o přípravku (SPC).
14. http://www.xalatan.cz/files/spc/pfizer/Zyvoxid/Zyvoxid_ SPC_25jun09.pdf
15. Gauduchon, V., Cozon, G., Vandenesch, F. et al. Neutralization of Staphylococcus aureus Panton-Valentine leukocidin by intravenous immunoglobulin in vitro. J. Infect. Dis., 2004, 189, 2, p. 346–353.
16. Morgan, M. S. Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int. J. Antimicrob. Agents, 2007, 30, 4, p. 289–296.
17. Napolitano, L. M., Brunsvold, M. E., Reddy, R. C., Hyzy, R. C. Community-acquired methicillin-resistant Staphylococcus aureus pneumonia and ARDS. Chest, 2009, 136, 5, p. 1407–1412.
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Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2010 Issue 6
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