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The role of linezolide in the treatment of resistant gram-positive infections


Authors: P. Dlouhý 1;  I. Herold 2;  M. Kolář 3;  J. Beneš 4;  P. Cetkovský 5;  T. Doležal 6;  D. Jahoda 7;  M. Kouba 8;  I. Novák 9;  O. Nyč 10;  J. Pilnáček 11;  Z. Ráčil 12;  T. Sechser 13;  P. Ševčík 14;  P. Švihovec 15
Authors‘ workplace: Infekční oddělení Masarykovy nemocnice v Ústí nad Labem 1;  Anesteziologicko-resuscitační oddělení Klaudiánovy nemocnice, Mladá Boleslav 2;  Ústav mikrobiologie FNO a LF UP, Olomouc 3;  II. infekční klinika 3. LF UK a FN Na Bulovce, Praha 4;  Ústav hematologie a krevní transfuze, Praha 5;  Ústav farmakologie 3. LF UK, Praha 6;  Ortopedická klinika 1. LF UK a FN Motol, Praha 7;  Ústav hematologie a krevní transfuze, Praha 8;  1. interní klinika LF UK a FN Plzeň 9;  Ústav lékařské mikrobiologie 2. LF UK, Praha 10;  Ortopedicko-úrazové oddělení, Nemocnice Kladno 11;  Interní hematoonkologická klinika, LF MU a FN Brno 12;  Pracoviště klinické farmakologie Centra diabetologie IKEM, Praha 13;  Anesteziologicko-resuscitační klinika, FN U sv. Anny, Brno 14;  Gynekologicko-porodnická klinika, Všeobecná fakultní nemocnice, Praha 15
Published in: Anest. intenziv. Med., 16, 2005, č. 6, s. 305-312
Category: Intensive Care Medicine - Original Paper

Overview

Incidence of gram-positive infections caused by bacteria resistant to commonly used antibiotics has been on the increase in the past decades. Resistant strains appeared in the Czech Republic later than in other countries, however their number has been increasing and the use of new antibiotics is becoming necessary. The greatest increase of incidence can be seen in infections caused by methicillin-resistant S. aureus and coagulase-negative staphylococci. Vancomycin-resistant enterococci are usually found in hemato-oncology patients. The curative use of vancomycin is limited due to its narrow therapeutical range, nephrotoxicity and limited penetration into tissues (lung) and CSF. Linezolide is a good option mainly in infections of skin and soft tissues, and it has an evincible advantage over vancomycin in the treatment of nosocomial pneumonia and surgical-site infections. Oral forms are favourable allowing switch therapy and earlier discharge from hospital.

Key words:
resistant bacteria – antibiotics – treatment of nosocomial pneumonia – linezolide – MRSA


Labels
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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