Protilátka anti-K blokující vyšetření antigenu

Česká verze

Authors: J. Tylečková; K. Tůmová; H. Lejdarová
Authors place of work: Transfuzní a tkáňové oddělení, FN Brno
Published in the journal: Transfuze Hematol. dnes,29, 2023, No. 2, p. 142-145.
Category: Kazuistiky
doi: https://doi.org/10.48095/cctahd2023prolekare.cz7

Summary

Haemolytic disease of the foetus and new-born due to anti-K antibodies is rare, but can cause severe foetal anaemia. Correct evaluation of immune-haematological tests is essential for providing proper treatment. One of the complications of laboratory testing can be a false negative result of erythrocyte antigen typing in a sample of foetal or new-born blood, due to an antibody blocking the antigen. This can be suspected in the event of a strongly positive direct antiglobulin test and the absence of the antigen corresponding to the identified antibody. This case report describes the situation we encountered when preparing an intrauterine transfusion for a pregnant woman with a Kell positive foetus and an anti-K antibody.

Keywords:

haemolytic disease of the foetus and new-born – red blood cell antibodies – blocked antigen – maternal anti-K

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