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Fezolinetant, the neurokinin 3 receptor antagonist in the treatment of vasomotor symptoms in perimenopause


Authors: P. Křepelka
Authors‘ workplace: Ředitel: doc. MUDr. Jaroslav Feyereisl, CSc. ;  Ústav pro péči o matku a dítě, Praha
Published in: Prakt. Lék. 2024; 104(1): 14-16
Category: Of different specialties

Overview

Vasomotor symptoms in perimenopause (VMS) represent the most common health problem of menopausal women with a significant impact on their quality of life. The results of large clinical trials have led physicians and patients to question the safety of hormone therapy in perimenopause. Currently, there is evidence of high effectiveness and safety of hormone therapy in the treatment of vasomotor symptoms of menopausal syndrome, provided that contraindications to hormone therapy are respected and the risk-benefit ratio of treatment is individually assessed for each patient. Non-hormonal treatment modalities are available for women with contraindications to hormone therapy. A new perspective in the treatment of VMS is the neurokinin 3 receptor antagonist fezolinetant.

Keywords:

menopause – vasomotor symptoms – hormone therapy – hot flashes – perimenopause – neurokinin 3 receptor antagonists – fezolinetant


Sources
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adresa pro korespondenci:
MUDr. Petr Křepelka, Ph.D.
Ústav pro péči o matku a dítě
Podolské nábřeží 157, 147 00 Praha 4 – Podolí
e-mail:
petr.krepelka@upmd.eu

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General practitioner for children and adolescents General practitioner for adults
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