Jsou sérový neutrofilní delta index a systémový zánětlivý index užitečné jako prediktivní parametry preeklampsie a HELLP syndromu?

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Autoři: Y. Dal ¹ ; Ş. Karagün ¹ ; F. Akkuş ² ; K. Akay ³ ; A. Coşkun ¹
Působiště autorů: Department of Obstetrics and Gynecology, Perinatology Department, Mersin University Faculty of Medicine, Mersin, Turkey ¹; Department of Obstetrics and Gynecology, Perinatology Department, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey ²; Department of Obstetrics and Gynecology, Mersin University Faculty of Medicine, Mersin, Turkey ³
Vyšlo v časopise: Ceska Gynekol 2023; 88(6): 412-419
Kategorie: Původní práce
doi: https://doi.org/10.48095/cccg2023412

Souhrn

Cíl: Naším cílem bylo zjistit, zda sérový delta index neutrofilů a další parametry systémového zánětlivého indexu mohou mít při použití s jinými bio chemickými markery u preeklampsie a HELLP syndromu pomocný účinek v diagnostice a určit roli zánětu v patogenezi těchto onemocnění. Materiál a metody: Do studie bylo zahrnuto 121 těhotných žen, které splnily kritéria pro zařazení a vyloučení. Do sledované skupiny bylo zařazeno 52 těhotných s diagnostikovanou preeklampsií, 19 těhotných s diagnostikovaným HELLP syndromem a do kontrolní skupiny 50 zdravých těhotných žen. Demografické údaje, hematologické a bio chemické parametry a zánětlivé markery (sérový neutrofilní delta index – DNI – a systémové parametry zánětlivého indexu) skupin byly zaznamenány a porovnány mezi skupinami. Výsledky: Z hlediska poměru neutrofilních lymfocytů, poměru lymfocytů trombocytů a DNI byla skupina HELLP odlišná od obou skupin. Kontrolní skupina a skupina s preeklampsií byly podobné. Z hlediska poměru monocytů k lymfocytům byla skupina preeklampsie odlišná od obou skupin. Kontrolní a HELLP skupiny byly podobné. Z hlediska indexu systémového zánětu byly všechny skupiny podobné. Závěr: V naší studii jsme zjistili, že využití DNI v mateřském séru spolu s dalšími bio chemickými parametry může pomoci v diagnostice preeklampsie a HELLP syndromu a zánět může hrát roli v patogenezi těchto onemocnění.

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