Relation of the Severity of Atopic Dermatitis and Occurrence of Respiratory Allergy to Dust, Animal Dander, Mites, Feather and IgE Food Allergy to Cow´s Milk, Egg, Soy, Peanuts and Wheat

Czech version

Authors: J. Čelakovská
Authors‘ workplace: Klinika nemocí kožních a pohlavních FN a LF UK Hradec Králové přednosta doc. MUDr. Miloslav Salavec, CSc.
Published in: Čes-slov Derm, 91, 2016, No. 6, p. 274-283
Category: Pharmacologyand Therapy, Clinical Trials

Overview

The aim of this study is the evaluation of the relationship between the severity of atopic dermatitis (assessed by SCORAD index) and the occurrence of food allergy and food sensitisation to cow´s milk, wheat, egg, soy, peanuts, and sensitisation to mites, feather, animal dander, and dust. The complete dermatological and allergological examinations were performed and the severity of atopic dermatitis was evaluated with use of SCORAD index. The statistical evaluation of the dependence between the occurrence of food allergy, food sensitisation, sensitisation to inhalant allergens and the severity of atopic dermatitis was performed. Two hundred and eighty-three patients were examined, 89 men and 194 women, average age 26.2. The significant relation was detected between the severity of atopic dermatitis and sensitisation to all tested inhalant allergens; no significant relation was detected between the severity of atopic dermatitis and food allergy or food sensitisation to tested food allergens. The significant relation was observed between the late type allergic food reaction and the severity of atopic dermatitis.

Key words:
atopic dermatitis – food allergy to cow’s milk, wheat, egg, soy, peanuts – sensitisation to mites, feather, animal dander, dust – severity of atopic dermatitis – SCORAD index

Sources

1. BARKER. J., PALMER, C., ZHAO, Y. et al. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J. Invest. Dermatol., 2007, 127, p. 564–567.

2. BIEBER, T., LEUNG, D. Atopic dermatitis. Marcel Dekker: New York, 2002, p. 365.

3. BOGUNIEWICZ, M., LEUNG, D. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol. Rev., 2011, 242, p. 233–246.

4. BUSSMANN, C., BÖCKENHOFF, A., HENKE, H., WERFEL, T., NOVAK, N. Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis? J. Allergy Clin. Immunol., 2006, 118, 6, p. 1292–1298.

5. BROUGH, H., LIU, A., SICHERER, S., MAKINSON, K., DOUIRI, A., BROWN, S., STEPHENS, A., IRWIN MCLEAN, W., TURCANU, V., WOOD, R. et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J. Allergy Clin. Immunol., 2015, 135, 164–170.

6. CARSWELL, F., THOMPSON, S. Does natural sensitisation in eczema occur through the skin? Lancet, 1986, 2, p. 13–15.

7. ČELAKOVSKÁ, J., BUKAČ, J., ETTLER, K. Food hypersensitivity reactions in atopic dermatitis patients and analysis of contomitant diseases. Food and Agricultural Immunology, 2015, 26, 2, p. 260–270.

8. ČELAKOVSKÁ, J., BUKAČ, J. Food allergy in patients suffering from atopic dermatitis – association with concomitant allergic diseases. Food and Agricultural Immunology, 26, 3, p. 325–339.

9. ČELAKOVSKÁ, J., BUKAČ, J. The severity of atopic dermatitis and analysis of the food hypersensitivity reactions. Food and Agricultural Immunology, 2015, 26, 6, p. 896–908.

10. ČELAKOVSKÁ, J., ETTLEROVÁ, K., ETTLER, K., VANĚČKOVÁ, J., BUKAČ, J. Sensitization to aeroallergens in atopic dermatitis patients: association with concomitant allergic diseases. J. Eur. Acad. Dermatol. Venereol., 2015, 8, p. 1500–1505.

11. ČELAKOVSKÁ, J., ETTLEROVA, K., ETTLER, K., et al. Evaluation of food allergy to wheat, cow milk, egg, soy and peanuts in patients suffering from atopic dermatitis. Food and Agricultural Immunology, 2015, 26, 1, p. 26–37.

12. DAI, Y. Allergens in atopic dermatitis. Clin. Rev. Allergy Immunol., 2007, 33, 3, p. 157–166.

13. DELEURAN, M., ELLINGSEN, E., PALULDAN, K. et al. Purified Der p1 and p2 patch tests in patients with atopic dermatitis: evidence for both allergenicity and proteolytic irritancy. Acta Derm-Venereol., 1998, 78, p. 241–243.

14. DU TOIT, G., ROBERTS, G., SAYRE, P., BAHNSON, H., RADULOVIC, S., SANTOS, A., BROUGH, H., PHIPPARD, D., BASTING, M., FEENEY, M., et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N. Engl. J. Med., 2015, 372, p. 803–813.

15. DU TOIT, G., LACK, G. Can food allergy be prevented? The current evidence. Pediatr. Clin. N. Am., 2011, 58, 481–509.

16. EUROPEAN TASK FORCE ON ATOPIC DERMATITIS. Severity scoring of atopic dermatitis: the SCORAD Index (consensus report of the European Task Force on Atopic Dermatitis). Dermatology, 1993, 186, p. 23–31.

17. FALLON, P., SASAKI, T., SANDILANDS, A. et al. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat. Genet, 2009, 41, p. 602–608.

18. GELMETTI, C., COLONNA, C. The value of SCORAD and beyond. Towards a standardized evaluation of severity? Allergy, 2004, 59 (Suppl. 78), p. 61–65.

19. HANIFIN, J., RAJKA, G. Diagnostic features of atopic dermatitis. Acta Derm. Venereol., 1980, 92, p. 44–47.

20. HOWELL, M., KIM, B., GAO, P., GRANT, A., BOGUNIEWICZ, M., DEBENEDETTO A. et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J. Allergy Clin. Immunol., 2007, 120, p. 150–155.

21. JEONG, S., KIM, H., YOUM, J. et al. Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. J. Invest. Dermatol., 2008, 128(8), p. 1930–1939.

22. KIM, B., LEUNG, D., BOGUNIEWICZ, M., HOWELL, M. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin. Immunol., 2008, 126, p. 332–337.

23. KUTLU, A., KARABACAK, E., AYDIN, E., OZTURK, S., TASKAPAN, O., AYDINOZ, S., BOZKURT, B. Relationship between skin prick and atopic patch test reactivity to aeroallergens and disease severity in children with atopic dermatitis. Allergol. Immunopathol., 2013, 41, 6, p. 369–373.

24. LASKE, N., NIGGEMANN, B. Does the severity of atopic dermatitis correlate with serum IgE levels? Pediatr. Allergy Immunol., 2004, 15, 1, p. 86–88.

25. NEMOTO-HASEBE, I., AKIYAMA, M., NOMURA, T. et al. Clinical severity correlates with impaired barrier in filaggrin-related eczema. J. Invest. Dermatol., 2009, 129, p. 682–689.

26. OYOSHI, M., OETTGEN, H., CHATILA, T., GEHA, R., BRYCE, P. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J. Allergy Clin. Immunol., 2014, 133, 309–317.

27. RÖCKMANN, H., VAN GEEL, M., KNULST, A., HUISKES, J., BRUIJNZEEL-KOOMEN, C., DE BRUIN-WELLER, M. Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis. Clin. Transl. Allergy, 2014, 28, 4, 1, p. 9.

28. SCHÄFER, T., HEINRICH, J., WJST, M., ADAM, H., RING, J., WICHMANN, H. Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren. J. Allergy Clin. Immunol., 1999, 104, 6, p. 1280–1284.

29. SPERGEL J. Epidemiology of atopic dermatitis and atopic march in children. Immunol. Allergy Clin. North. Am., 2010, 30, p. 269–280.

30. TUPKER, R., DE MONCHY, J., COENRAADS, P. et al. Induction of atopic dermatitis by inhalation of house dust mite. J. Allergy Clin. Immunol., 1996, 97, p. 1064–1070.

31. VAN DEN OORD, R., SHEIKH, A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. BMJ, 2009, 339, b2433.

32. WAN, H., WINTON, H., SOELLER, C., TOVEY, E., GRUENER, D., THOMPSON, P. et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest., 1999, 104, p. 123–133.

33. WAN, H., WINTON, H., SOELLER, C., TAYLOR, G., GRUENERT, D., THOMPSON, P. et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin. Exp. Allergy, 2001, 31, p. 279–294.

34. WEIDINGER, S., ILLIG, T., BAURECHT, H., IRVINE, A., RODRIGUEZ, E., DIAZ-LACAVA, A. et al. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J. Allergy Clin. Immunol., 2006, 118, p. 214–219.

35. ZEPPA, L., BELLINI, V., LISI, P. Atopic dermatitis in adults. Dermatitis, 2011, 22, p. 40–46.

Labels

Dermatology & STDs Paediatric dermatology & STDs Allergology and clinical immunology General practitioner for children and adolescents

Localised Scleroderma and Morphea: Current State of Knowledge and Therapy

Bilateral Giant Cell Temporal Arteritis – Case Report

Article was published in

Czech-Slovak Dermatology

2016 Issue 6