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Efficacy of Combination Therapy for Chronic Lymphocytic Leukemia in Patients with Complex Karyotype
A complex karyotype (presence of ≥ 3 chromosomal abnormalities) is a negative prognostic marker in chronic lymphocytic leukemia (CLL). An analysis of the impact of complex karyotype on the efficacy of targeted CLL therapy combining the monoclonal antibody against CD20 antigen obinutuzumab with the BCL2 inhibitor venetoclax or the alkylating cytostatic chlorambucil was published in the journal Blood.
Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs
In the context of the significant advancements in the field of immunotherapy and evidence of its…
Recommendations for the diagnosis of ITP in adults and children according to ASH guidelines
The American Society of Hematology (ASH) guidelines from 2019 highlighted several important aspects…
Current ASH Guidelines on ITP Management 2019 – Recommendations for Newly Diagnosed ITP in Children
At the end of 2019, the American Society of Hematology (ASH) published current guidelines for…
Clinical Results of the Pinnacle Acetabular System: Data from the UK Joint Replacement Registry
The Pinnacle Acetabular System has been available on the market for nearly two decades. Since then,…
Incontinence Dermatitis - Common, Yet Often Overlooked Diagnosis
Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%,…
Through Obstacles to the Stars – Path to Developing a Healthy Gut Microbiota in Children: What Blocks It and What Helps?
The gut microbiota is acquired by an individual during the first 2 years of life. The main source…
FOLFOXIRI and Panitumumab in mCRC Treatment – Improvement in Treatment Response and Metastasis Resectability
For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment,…
Early Cytoreductive Treatment Delays Onset of Symptoms Associated with Metastatic Colorectal Carcinoma
Managing symptoms associated with advanced cancer has a significant impact on patients' quality of…
Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement…