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News Pharmacological Profile of Mavacamten and Key Studies of Its Use in HCM Treatment
A new addition to the treatment options for hypertrophic cardiomyopathy, approved for use in European Union countries in June 2023, is the selective reversible cardiac myosin inhibitor mavacamten. The following review summarizes its fundamental pharmacological characteristics along with the results of several crucial clinical studies and highlights the potential integration of mavacamten into clinical practice.
News How can inosine pranobex help with viral infections?
Inosine pranobex has long been used for its immunomodulatory and antiviral effects in the prophylaxis and therapy of various viral infections. Below we summarize its mechanism of action, indications, usage, and side effects.
News Does Dosage Frequency Matter for Adherence to Anticholinergic Treatment in Patients with COPD?
A study by Spanish authors compared the adherence of patients with chronic obstructive pulmonary disease (COPD) to anticholinergic treatment administered once every 12 hours and once every 24 hours.
News Idiopathic Pulmonary Fibrosis from the Perspective of an Outpatient Pulmonologist
Idiopathic pulmonary fibrosis represents a rare disease of lung tissue with an as-yet-unexplained etiology. In the framework of differential diagnosis, it is necessary to consider the disease, as early diagnosis combined with the deployment of antifibrotic therapy extends patients' lives.
News Reduction of LDL Cholesterol in the Prevention of Cardiovascular Morbidity and Mortality – Results of a Large Meta-Analysis
Elevated LDL cholesterol (LDL-c) is one of the main causes of atherosclerosis. The meta-analysis presented below examined the effect of reducing its levels on the risk of cardiovascular (CV) morbidity and mortality.
News Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome
Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of concomitant cardiomyopathy is not yet fully understood. Japanese researchers from Kumamoto University recently focused on the relationship between carpal tunnel syndrome and cardiac amyloidosis in their newly published prospective study.
News Adjuvant Treatment of Early Invasive HER2+ Breast Cancer − Results of the Katherine Study
Women with breast cancer found to have residual invasive disease during surgery after neoadjuvant chemotherapy and HER2-targeted therapy have a significantly worse prognosis. For these patients, the Czech Oncology Society ČLS JEP recommends adjuvant therapy with trastuzumab emtansine based on data from the Katherine clinical study. However, this treatment has not yet been covered by public health insurance, with reimbursement starting from March 1, 2021.
News Eletriptan as an effective and safe drug in acute migraine therapy
In the pharmacotherapy of acute migraine attacks, a pharmacologically diverse group of triptans is particularly used. The choice of the right antimigraine drug should be individualized, based on the intersection of the patient's nature of complaints and the pharmacological profile of the drug. The following text briefly summarizes the basic characteristics and profile of eletriptan.
News Efficacy of Empagliflozin in HFpEF Patients – Comparison of Subpopulations with Preserved and Mid-Range LV EF
A sub-analysis of the EMPEROR-Preserved clinical trial examined the effects and safety of empagliflozin in patients with heart failure with a left ventricular ejection fraction (LV EF) > 40%. What insights does it provide regarding the impact on cardiovascular (CV) mortality or the need for hospitalization for heart failure (HHF) concerning left ventricular function?
News Efficacy and Tolerance of Dorzolamide/Timolol Combination With and Without Preservatives in Patients With Elevated Intraocular Pressure
The fixed combination of the carbonic anhydrase inhibitor dorzolamide and the locally acting beta-blocker timolol is indicated for the treatment of elevated intraocular pressure in patients with open-angle glaucoma. The comparison of the efficacy and tolerance of this combination with preservatives, associated among other things with eye irritation, and without them was the subject of the American study presented below.
News Importance of Home Parenteral Therapy: ESPEN Recommendations from 2020
Home parenteral therapy currently plays a crucial role in the treatment and prevention of malnutrition in specific patient groups. The European Society for Clinical Nutrition and Metabolism (ESPEN) published updated guidelines for home parenteral therapy in 2020, based on current evidence and expert recommendations.
News Recommend Erdostein for children when treating with amoxicillin – symptoms of cough improve in almost 50% of cases within 3 days
Acute respiratory infections are usually treated empirically in primary care as the causative agent is not known. Amoxicillin is among the most commonly chosen antibiotics. Erdostein is a suitable addition to this antibiotic treatment for several reasons.
News Primum non nocere applies not only in medicine: an ecological look at inhalers
According to estimates from the World Health Organization (WHO), around 65 million people worldwide suffer from mild to moderate forms of chronic obstructive pulmonary disease (COPD). The cornerstone of therapy is the inhalation administration of bronchodilator drugs. While there is no doubt that this therapy helps patients, what impact do the propellants in inhalation systems have on the global climate? And is there a sensible solution to this problem?
News Pegylated Liposomal Irinotecan + 5-FU/LV in the Treatment of mPDAC in Czech Clinical Practice – Results from the VILP Registry
At last year's annual congress of the European Society for Medical Oncology (ESMO) and this year's 15th PragueONCO, results from the Czech VILP registry were presented. This registry collected data on patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with pegylated liposomal irinotecan (nal-IRI) in combination with 5-fluorouracil (5-FU) and leucovorin (LV). The efficacy and safety of nal-IRI + 5-FU/LV in patients with mPDAC after failure or intolerance to gemcitabine-based chemotherapy, as found in the randomized controlled study NAPOLI-1, are thus confirmed in real clinical practice in the Czech Republic.
News Systemic Manifestations of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the symptoms of right ventricular failure and pulmonary circulation impairment, patients with PAH also exhibit changes in other organ systems.
News Overall Survival in Patients with Metastatic CRC During 1st-Line Anti-EGFR Treatment Depending on the Presence or Absence of Hypomagnesemia
Hypomagnesemia is one of the side effects of monoclonal antibody therapy against the epidermal growth factor receptor (EGFR). The study presented below examined overall survival in patients with metastatic primarily unresectable colorectal cancer (CRC) treated with anti-EGFR therapy depending on the presence or absence of hypomagnesemia.