Evaluation of blood counts and schistocytes in the peripheral blood smear
Authors:
D. Mikulenková
Authors‘ workplace:
Ústav hematologie a krevní transfuze
Published in:
Transfuze Hematol. dnes,29, 2023, No. Supplementum 3, p. 22-26.
Category:
doi:
https://doi.org/10.48095/cctahd20233S22
Overview
Microscopic evaluation of the peripheral blood smear is a basic examination that can help uncover the cause of pathological values in the blood count. Excess schistocytes, as well as anaemia and thrombocytopenia, warn of the possible presence of microangiopathic haemolytic anaemia. These findings are followed by other tests to determine the cause of these changes and establish the correct diagnosis. The reference limit for schistocytes in peripheral blood smears has been newly defined for adults, premature infants and haematopoietic tissue cell transplant recipients. The article is based on the revised recommendations of the Czech Society of Haematology (CHS), the recommendations of the International Council for Standardization in Haematology and our own laboratory experience.
Keywords:
schistocyte – microangiopathic haemolytic anaemia – thrombotic microangiopathy
Sources
1. Zini G, d‘Onofrio G, Biggs C, et al. ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. Int J Lab Hematol. 2012; 34: 107–116.
2. Zini G, d‘Onofrio G, Erber WN, et al. 2021 update of the 2012 ICSH recommendations for identification diagnostic value and quantitation of schistocytes: impact and revisions. Int J Lab Hematol. 2021; 43: 1264–1271.
3. Doporučení LS ČHS Příprava a barvení nátěru periferní krve a aspirátu kostní dřeně, včetně kontrolní činnosti, v aktuální verzi. [online]. Dostupné z: https: //labsekce.hematology.cz.
4. Sukumar S, Lämmle B, Cataland SR. Thrombotic thrombocytopenic purpura: pathophysiology, diagnosis, and management. J Clin Med. 2021; 10 (3): 536.
5. Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol. 2005; 16 (4): 1035–1050.
6. Ryšavá R. Atypický hemolyticko-uremický syndrom a současné názory na jeho léčbu. Interní Med. 2017; 19 (3): 116–124.
7. El-Gamal RA, Mekawy MA, Abd Elkader AM, Abdelbary HM, Fayek MZ. Combined immature platelet fraction and schistocyte count to differentiate pregnancy-associated thrombotic thrombocytopenic purpura from severe preeclampsia/haemolysis, elevated liver enzymes, and low platelet syndrome (SPE/HELLP). Indian J Hematol Blood Transfus. 2019; 36; 316–323.
8. Della Rocca DG, Magnocavallo M, Lavalle C, et al. Evidence of systemic endothelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease. J Thromb Thrombolysis. 2021; 51: 571–576.
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2023 Issue Supplementum 3
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