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Teklistamab with the latest two-year effi cacy and safety data in the treatment of RRMM


Published in: Transfuze Hematol. dnes,29, 2023, No. 3, p. 207-209.
Category:
doi: https://doi.org/10.48095/cctahd2023207

Overview

Teklistamab is the fi rst-in-class bispecifi c antibody against B-cell maturation antigen (BCMA) and CD3 receptor on the surface of T-lymphocytes used in the treatment of relapsed/ refractory multiple myeloma (RRMM). New long-term data demonstrate its sustained effi cacy in achieving deep therapeutic responses and maintaining them over time, even with an extended 2-week dosing regimen.

Keywords:

treatment response – Safety – overall survival – minimal residual disease – teklistamab – bispecifi c antibody – B-cell maturation antigen – CD3 T-lymphocytes – relapsed/ refractory multiple myeloma – progression-free survival


Sources

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3. Kumar SK, Callander NS, Adekola K, et al. Multiple myeloma, version 3.2021, NCCN clinical practice guidelines in on-cology. J Natl Compr Canc Netw. 2020; 18 (12): 1685–1717.

4. Mateos MV, Weisel K, De Stefano V, et al. LocoMMotion: a prospective, non-interventional, multinational study of real-life current standards of care in patients with relapsed and/or refractory multiple myeloma. Leukemia 2022; 36 (5): 1371–1376.

5. Moreau P, Garfall AL, van de Donk N, et al. Teclistamab in relapsed or refractory multiple myeloma. N Engl J Med. 2022; 387 (6): 495–505

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7. Usmani S, et al. Presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting; June 2–6, 2023; Chicago, IL, USA & Virtual.

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Labels
Haematology Internal medicine Clinical oncology
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