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Pitfalls of treating chronic myeloid leukaemia with dasatinib – pulmonary arterial hypertension as a rare complication


Authors: P. Čičátková;  A. Kvetková;  T. Horňák;  L. Semerád;  D. Žáčková
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU a FN Brno
Published in: Transfuze Hematol. dnes,27, 2021, No. 2, p. 166-171.
Category: Case Report
doi: https://doi.org/10.48095/cctahd2021166

Overview

Dasatinib is a potent tyrosine kinase inhibitor of not only Bcr-Abl1, but also of the Src kinase family, c-kit and PDGFR-â. This “off-target” effect is the probable cause of pleural effusions, which complicate dasatinib therapy in about one third of patients. The following case report describes a chronic myeloid leukaemia patient with not only recurrent pleural effusions but also pulmonary arterial hypertension as a serious adverse event leading to dasatinib discontinuation.

Keywords:

chronic myeloid leukaemia – dasatinib – pleural effusions – pulmonary arterial hypertension


Sources

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Labels
Haematology Internal medicine Clinical oncology

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Transfusion and Haematology Today

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2021 Issue 2

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