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Transformation of chronic lymphocytic leukaemia into Hodgkin lymphoma


Authors: S. Mašlejová;  A. Panovská;  Y. Brychtová;  M. Doubek
Authors‘ workplace: Interní hematologická a onkologická klinika, Fakultní nemocnice, Brno
Published in: Transfuze Hematol. dnes,26, 2020, No. 1, p. 61-64.
Category: Case Reports

Overview

The Hodgkin lymphoma variant of Richter transformation (HV-RS) is a rare, prognostically poor complication of chronic lymphocytic leukaemia (CLL), whereby CLL transforms into Hodgkin lymphoma. This case report presents a CLL patient, with histologically proven HV-RS diagnosed on ibrutinib therapy.

Keywords:

chronic lymphocytic leukaemia – Hodgkin lymphoma – Richter transformation


Sources

1. Janjetovic S, Bernd HW, Bokemeyer C, et al. Hodgkin’s lymphoma as a rare variant of Richter’s transformation in chronic lymphocytic leukemia: A case report and review of the literature. Mol Clin Oncol. 2016;4(3):390–392.

2. Mauro FR, Galieni P, Tedeschi A, et al. Factors predicting survival in chronic lymphocytic leukemia patients developing Richter syndrome transformation into Hodgkin lymphoma. Am J Hematol. 2017;92:529–535.

3. Bockorny B, Codreanu I, Dasanu CA. Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature. Br J Haematol. 2012;156:50–66.

4. Doubek M, Špaček M, Pospíšilová Š, et al. Doporučení pro diagnostiku a léčbu chronické lymfocytární leukemie (CLL) – 2018. Transfuze Hematol Dnes. 2018;24(3):208–220.

5. Parikh SA, Habermann TM, Chaffee KG, et al. Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novo Hodgkin lymphoma. Am J Hematol. 2015;90(4):334–338.

6. Xiao W, Chen WW, Sorbara L, et al. Hodgkin lymphoma variant of Richter transformation: morphology, Epstein-Barr virus status, clonality, and survival analysis - with comparison to Hodgkin-like lesion. Hum Pathol. 2016;55:108–116.

7. Tadmor T, Shvidel L, Goldschmidt N, et al. Hodgkin’s variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group. Anticancer Res. 2014;34(2):785–790.

8. Pospíšilová Š, Jarošová M, Doubek M. Chronická lymfocytární leukemie – současné využití moderních prognostických a prediktivních faktorů v diagnostice. Transfuze Hematol Dnes. 2019;25(4):66–71.

9. Kadri S, Lee, J, Fitzpatrick, C, et al. Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL. Blood Adv. 2017;1(12):715–727.

10. Innocenti I, Rossi D, Trapè G, et al. Clinical, pathological, and biological characterization of Richter syndrome developing after ibrutinib treatment for relapsed chronic lymphocytic leukemia. Hematol Oncol. 2018;36:600–603.

Labels
Haematology Internal medicine Clinical oncology

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Transfusion and Haematology Today

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2020 Issue 1

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