Long-term storage and disposal of cryopreserved grafts – recommendations of the Transplant Section of the Czech Society of Haematology
Authors:
D. Lysák 1; M. Karas 1; P. Jindra 1; P. Sedláček 2; Z. Kořístek 3; T. Kozák 4; E. Faber 5; M. Trněný 6; P. Žák 7; P. Měřička 7; M. Krejčí 8; R. Pacasová 9; A. Vítek 10; R. Pytlík 10
Authors‘ workplace:
Hematologicko-onkologické oddělení Fakultní nemocnice Plzeň
1; Klinika dětské hematologie a onkologie, Fakultní nemocnice Motol, Praha
2; Klinika hematoonkologie, Fakultní nemocnice Ostrava
3; Interní hematoonkologická klinika, Fakultní nemocnice Královské Vinohrady, Praha
4; Hemato-onkologická klinika, Fakultní nemocnice Olomouc
5; I. interní klinika, Všeobecná fakultní nemocnice, Praha
6; IV. Interní hematologická klinika, Fakultní nemocnice Hradec Králové
7; Interní hematologická a onkologická klinika, Fakultní nemocnice Brno
8; Transfuzní a tkáňové oddělení, Fakultní nemocnice Brno
9; Ústav hematologie a krevní transfuze, Praha
10
Published in:
Transfuze Hematol. dnes,24, 2018, No. 4, p. 298-303.
Category:
Overview
Cryopreservation of haematopoietic stem cells represents a common method used to support autologous transplantation or to process allogeneic collections. Most transplant centres are struggling with an increasing number of unused long-term stored transplants on one hand and the absence of generally accepted rules for their disposal on the other. The goal of the recommendations is to offer a set of measures to ensure the long-term storage and eventual disposal of cryopreserved products and to try and harmonize these at national level.
Key words:
graft – cryopreservation – disposal – storage
Sources
1. Passweg JR, Baldomero H, Bader P, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplant 2017;52:811–817.
2. Holbro A, Baldomero H, Lanza F, et al. Handling, processing and disposal of stem cell products in Europe: A survey by the cellular therapy and immunobiology working party of the European Society for Blood and Marrow Transplantation. Cytotherapy 2018;20(3):453–460.
3. Donnenberg AD, Koch EK, Griffin DL, et al. Viability of cryopreserved BM progenitor cells stored for more than a decade. Cytotherapy 2002;4:157–163.
4. Aird W, Labopin M, Gorin NC, et al. Long-term cryopreservation of human stem cells. Bone Marrow Transplant 1992;9:487–490.
5. Fernyhough LJ, Buchan VA, McArthur LT, et al. Relative recovery of haematopoietic stem cell products after cryogenic storage of up to 19 years. Bone Marrow Transplant 2013;48:32e5.
6. Phipps C, Linenberger M, Holmberg LA, et al. Utilization of stored autologous PBSCs to support second autologous transplantation in multiple myeloma patients in the era of novel agent therapy. Bone MarrowTransplant 2015;50:663–667.
7. Pavlů J, Auner HW, Szydlo RM, et al. Analysis of hematopoietic recovery after autologous transplantation as method of quality control for long-term progenitor cell cryopreservation. Bone Marrow Transplant 2017;52:1599–1601.
8. Olivieri J, Pierelli L, Introna M, et al. GITMO (Gruppo Italiano Trapianto di Midollo Osseo) – SIDEM (Società Italiana di Emaferesi e Manipolazione Cellulare) Working Group on SCU Disposal. Kinetics of the use of cryopreserved autologous stem cell grafts: a GITMO-SIDEM survey. Cytotherapy 2014;16:101–110.
9. Perseghin P, Marchetti M, Pierelli L, et al. Società Italiana di Emaferesi e Manipolazione Cellulare; Gruppo Italiano Trapianto Midollo Osseo; Centro Nazionale Trapianti. A policy for the disposal of autologous hematopoietic progenitor cells: report from an Italian consensus panel. Transfusion 2014;54:2353–2360.
10. Devadas SK, Khairnar M, Hiregoudar SS, et al. Is long term storage of cryopreserved stem cells for hematopoietic stem cell transplantation a worthwhile exercise in developing countries? Blood Res 2017;52:307–310.
11. Booth GS, Gehrie EA, Jagasia MH, et al. When can you discard stem cells? Biol Blood Marrow Transplant 2015;21:2033.
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2018 Issue 4
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