Diagnosis and prognostic factors in mantle cell lymphoma

Czech version

Authors: A. Obr ¹; M. Mikešová ¹; M. Jarošová ¹; V. Procházka ¹; B. Tessoulin ²; T. Papajík ¹
Authors‘ workplace: Université de Nantes et INSERM Centre Régional de Recherche en Cancérologie Nantes/Angers Unite Mixte de Recherche 892, Nantes, France ; Hemato-onkologická klinika LF UP a Fakultní nemocnice Olomouc ¹; CHU de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie, Nantes, France ²
Published in: Transfuze Hematol. dnes,22, 2016, No. 3, p. 190-200.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Mantle cell lymphoma (MCL) was first described as a diagnostic entity in the R.E.A.L. (Revised European-American Classification of Lymphoid Neoplasms) classification in 1994. MCL is a malignant disease arising from B-lymphocytes. It is characterised by overexpression of cyclin D1 and by chromosomal translocation t(11;14)(q13;q32). The origin of tumour cells is inner mantle zone of lymphatic follicles. MCL is substantially heterogeneous disease by its morphologic and biologic characteristics. Clinical course can be really slow in indolent form of the disease or conversely very quick in aggressive form of MCL. Strict diagnostics and careful evaluation of prognostic markers are important in patients with this kind of lymphoma because of its biologic and clinical heterogeneity

KEY WORDS:
mantle cell lymphoma – immunophenotype – cytogenetic changes – positron emission tomography – prognosis

Sources

1. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392.

2. Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC 2008: 229–232.

3. Raffeld M, Jaffe ES. bcl-1, t(11;14), and mantle cell-derived lymphomas. Blood 1991; 78: 259–263.

4. Banks PM, Chan J, Cleary ML, et al. Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 1992; 16: 637–640.

5. Dreyling M, Geisler C, Hermine O, et al. Newly Diagnosed and Relapsed Mantle Cell Lymphoma: ESMO Clinical Practice Guidelines. Ann Oncol 2014; 25 (suppl 3): iii83–iii92.

6. Schollkopf C, Melbye M, Munksgaard L, et al. Borrelia infection and risk of non-Hodgkin lymphoma. Blood 2008.

7. Cortelazzo S, Ponzoni M, Ferreri AJ, Dreyling M. Mantle cell lymphoma. Critical Reviews in Oncology/Hematology 2012; 82(1): 78–101.

8. Clapp RW, Jacobs MM, Loechler EL. Environmental and occupational causes of cancer: new evidence 2005–2007. Rev Environ Health 2008; 23: 1–37.

9. Eriksson M, Hardell L, Carlberg M, Akerman M. Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis. Int J Cancer 2008; 123: 1657–1663.

10. Zhang Y, Dai Y, Zheng T, Ma S. Risk factors of Non-Hodgkin lymphoma. Expert Opinion on Medical Diagnostics 2011; 5: 539–550.

11. Tort F, Camacho E, Bosch F, Harris NL, Montserrat E, Campo E. Familial lymphoid neoplasms in patients with mantle cell lymphoma. Haematologica 2004; 89(3): 314–319.

12. Ondrejka SL, Lai R, Kumar N, Smith SD, Hsi ED. Indolent mantle cell leukemia: clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, κ light chain restriction, and good prognosis. Haematologica 2011; 96: 1221–1227.

13. Vogt N, Klapper W. Variability in morphology and cell proliferation in sequential biopsies of mantle cell lymphoma at diagnosis and relapse: clinical correlation and insights into disease progression. Histopathology 2013; 62(2): 334–342.

14. Bernard M, Gressin R, Lefrère F, et al. Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype. Leukemia 2001; 15(11): 1785–1791.

15. Duggan MJ, Weisenburger DD, Ye YL, et al. Mantle zone lymphoma. A clinicopathologic study of 22 cases. Cancer 1990; 66: 522–529.

16. Swerdlow SH, Habeshaw JA, Murray LJ, et al. Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse. AmJ Pathol 1983; 113: 181–197.

17. Weisenburger DD, Kim H, Rappaport H. Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer 1982; 49: 1429–1438.

18. Aqel N, Barker F, Patel K, Naresh KN. In-situ mantle cell lymphoma – a report of two cases. Histopathology 2008; 52: 256–260.

19. Gao J, Peterson L, Nelson B, Goolsby C, Chen YH. Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol 2009; 132: 699–706.

20. Gualco G, Weiss LM, Harrington WJ Jr, Bacchi CE. BCL6, MUM1, and CD10 expression in mantle cell lymphoma. Appl Immunohistochem Mol Morphol 2010; 18: 103–108.

21. Fu K, Weisenburger DD, Greiner TC, et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profıling. Blood 2005; 106: 4315–4321.

22. Rimokh R, Berger F, Delsol G, et al. Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas. Blood 1994; 83: 1871–1875.

23. Wlodarska I, Meeus P, Stul M, et al. Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma. Leukemia 2004; 18(10): 1705–1710.

24. Rocha CK, Praulich I, Gehrke I, Hallek M, and Kreuzer KA. A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report. Mol Cytogenet 2011; 4(1): 8.

25. Fu K, Weisenburger DD, Greiner TC, et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profıling. Blood 2005; 106: 4315–4321.

26. Salaverria I, Royo C, Carvajal-Cuenca A, et al. CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. Blood 2013; 121(8): 1394–1402.

27. Wlodarska I, Dierickx D, Vanhentenrijk V, et al. Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. Blood 2008; 111(12): 5683–5690.

28. Dictor M, Ek S, Sundberg M, et al. Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt’s lymphoma. Haematologica 2009; 94(11): 1563–1568.

29. Mozos A, Royo C, Hartmann E, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica 2009; 94(11): 1555–1562.

30. Narurkar R, Alkayem M, Liu D. SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Biomark Res 2016; 4: 6. Review.

31. Argatoff LH, Connors JM, Klasa RJ, et al. Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 1997; 89: 2067.

32. Cheah CY, George A, Giné E, et al. Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network. Ann Oncol 2013; 24: 2119.

33. American Joint Committee on Cancer. Lymphoid neoplasms. AJCC Cancer Staging Manual. 6th ed. New York: Springer 2002: 393–406

34. Lister TA, Crowther D, Sutcliffe SB et al. Report of a commitee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds Meeting. J Clin Oncol 1989; 7(11): 1630–1636.

35. Sýkorová A, Belada D, Smolej L, et al. Určování rozsahu onemocnění u non-Hodgkinových lymfomů – doporučení Kooperativní lymfomové skupiny. Klin Onkol 2010; 23(3): 146–154.

36. Barrington SF, Mikhaeel NG, Kostakoglu L, et al. Role of Imaging in the Staging and Response Assessment of Lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. JCO 2014; 32 (27): 3048–3058.

37. Martin P, Chadburn A, Christos P, et al. Outcome of deferred initial therapy in mantle-cell lymphoma. J Clin Oncol 2009; 27: 1209–1213.

38. Martin P, Leonard J. Is there a role for “watch and wait” in patients with mantle cell lymphoma? Semin Hematol 2011; 48(3): 189–193.

39. Hoster E, Dreyling M, Klapper W, et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood 2008; 111: 558.

40. Klapper W, Hoster E, Determann O, et al. European MCL Network. Ki-67 as a prognostic marker in mantle cell lymphoma-consensus guidelines of the pathology panel of the European MCL Network. J Hematol 2009; 2: 103–111.

41. Dreyling M, Ferrero S, Vogt N, Klapper W, European MCL Network. New Paradigms in MCL: Is It Time to Risk-Stratify Treatment Based on the Proliferative Signature? Clin Cancer Res 2014; 20: 5194.

42. http://www.european-mcl.net/en/clinical_mipi.php

43. https://www.qxmd.com/calculate/calculator_149/mipi-mantle-cell-lymphoma-prognosis

44. Salek D, Vesela P, Boudova L, et al. Retrospective analysis of 235 unselected patients with mantle cell lymphoma confirms prognostic relevance of Mantle Cell Lymphoma International Prognostic Index and Ki-67 in the era of rituximab: long-term data from the Czech Lymphoma Project Database. Leuk Lymphoma 2014; 55(4): 802–810.

45. Trněný M, Klener P, Campr V, et al. The Outcome of Mantle Cell Lymphoma patients after Treatment Failure and Prognostic value of Secondary Mantle Cell International Prognostic Index (sec MIPI). Oral and Poster Abstracts ASH 2014.

46. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489–495.

47. Porrata LF, Ristow K, Markovic SN. Absolute monocyte count at diagnosis and survival in mantle cell lymphoma. Br J Haematol 2013; 163(4): 545–547.

48. Beà S, Ribas M, Hernández JM, et al. Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants. Blood 1999; 93(12): 4365–4374.

49. Pinyol M, Hernandez L, Cazorla M, et al. Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas. Blood 1997; 89(1): 272–280.

50. Espinet B, Salaverria I, Beà S, et al. Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma. Genes Chromosomes Cancer 2010; 49(5): 439–451.

51. Hernández L, Beà S, Pinyol M, et al. CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus. Cancer Res 2005; 65(6): 2199–2206.

52. Hao S, Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ. Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features. Mod Pathol 2002; 15(12): 1266–1272.

53. Michaux L, Wlodarska I, Theate I, et al. Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome. Ann Hematol 2004; 83(9): 578–583.

54. Greiner TC, Moynihan MJ, Chan WC, et al. p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 1996; 87(10): 4302–4310.

55. Greiner TC, Dasgupta C, Ho VV, et al. Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 2006; 103(7): 2352–2357.

56. Hartmann EM, Campo E, Wright G, et al. Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling. Blood 2010; 116(6): 953–961.

57. Kohlhammer H, Schwaenen C, Wessendorf S, et al. Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions. Blood 2004; 104(3): 795–801.

58. Martinez-Climent JA, Vizcarra E, Sanchez D, et al. Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma. Blood 2001; 98(12): 3479–3482.

59. Kridel R, Meissner B, Rogic S, et al. Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma. Blood 2012; 119(9): 1963–1971.

60. Beà S, Valdés-Mas R, Navarro A, et al. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci USA 2013; 110(45): 18250–18255.

61. Suguro M, Yoshida N, Umino A, et al. Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis. Cancer Sci 2014; 105(7): 897–904.

62. Fernàndez V, Salamero O, Espinet B, et al. Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma. Cancer Res 2010; 70(4): 1408–1418.

63. Nordström L, Sernbo S, Eden P, et al. SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma – a Nordic Lymphoma Group study. Br J Haematol 2014; 166(1): 98–108.

64. Meirav Kedmi, Irit Avivi, Ribakovsky E, et al. Is there a role for therapy response assessment with 2-[fluorine-18] fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography in mantle cell lymphoma? Leuk Lymphoma 2014; 55: 2484–2489.

65. Pott C, Hoster E, Delfau-Larue M-H, et al. Molecular remission is an independent predictor of clinical outcome in patients with mantle cell lymphoma after combined immunochemotherapy: a European MCL intergroup study. Blood 2010; 115(16): 3215–3223.

66. Hermine O, Hoster E, Walewski J, et al. Alternating courses of 3xCHOP and 3xDHAP plus rituximab followed by a high dose ARA-C containing myeloablative regimen and autologous stem cell transplantation increases overall survival when compared to 6 courses of CHOP plus rituximab followed by myeloablative radiochemotherapy and ASCT in mantle cell lymphoma: final analysis of the MCL Younger Trial of the European mantle cell lymphoma Network. Hematol Oncol 2012: abstract 151. Presented at: ASH Annual Meeting, Atlanta, GA, USA, 8–11 December 2012.

67. Cheminant M, Derrieux C, Touzart A, et al. Minimal residual disease monitoring by 8-color flow cytometry in mantle cell lymphoma: an EU-MCL and LYSA study. Haematologica 2016; 101(3): 336–345.

68. Andersen NS, Pedersen LB, Laurell A, et al. Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. J Clin Oncol 2009; 27(26): 4365–4370.

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