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Potential of histone deacetylase inhibitors (HDACi) in the treatment of paediatric TEL/AML1–positive acute lymphoblastic leukaemia


Authors: J. Stárková;  M. Zápotocký;  J. Trka
Authors‘ workplace: CLIP, Klinika dětské hematologie a onkologie, 2. lékařská fakulta, Univerzita Karlova v Praze a FN v Motole
Published in: Transfuze Hematol. dnes,14, 2008, No. 2, p. 50-54.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Histone deacetylase inhibitors (HDACi) represent useful tools in the study of biology of selected malignant cells and they also have a potential in the treatment. Histone deacetylation caused by TEL/AML1 fusion protein in the genotypically defined subgroup of paediatric acute lymphoblastic leukaemia is one of the proposed malignant transformation pathways. Experimental treatment of TEL/AML1–positive leukaemic cells with HDACi supports this theory and confirms the potential of HDACi in the treatment of this leukaemia subtype.

Key words:
histone deacetylase inhibitors (HDACi), paediatric acute lymphoblastic leukaemia, TEL/AML1


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