Advances in treatment of Ph-positive adult acute lymphoblastic leukaemia

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2. Ottmann OG, Wassmann B. Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2005; 118–122.

3. Pui Ch-H, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006; 354: 166–178.

4. Hoelzer D, Gökbuget N. Recent approaches in acute lymphoblastic leukemia in adults. Crit Rev Oncol Hematol 2000; 36: 49–58.

5. Dombret H, Gabert J, Boiron JM, et al. Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia - results of the prospective multicenter LALA-94 trial. Blood 2002; 100(7): 2357–2366.

6. Annino L, Vegna ML, Camera A, et al. Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study. Blood 2002; 99: 863–871.

7. Linker C, Damon L, Ries C, Navarro W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol 2002; 20: 2464–2471.

8. Kantarjian H, Thomas D, O’Brien S, et al. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphoblastic leukemia. Cancer 2004; 101: 2788–2801.

9. Larson RA, Dodge RK, Burns P, et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811. Blood 1995; 85: 2025–2037.

10. Doubek M, Mayer J, Kořístek Z, et al. Terapie akutní lymfoblastické leukemie dospělých kombinací sedmi chemoterapeutik v indukční léčbě, intenzivní konzolidací s autologní transplantací kmenových buněk krvetvorby nebo bez ní a s následnou udržovací léčbou. Čas Lék Česk 2002; 141(4): 122–126.

11. Maaloufová J, Pytlík R, Gregora E, Procházka B, Kozák T. Léčba akutních lymfoblastických leukémií u dospělých: možnost intenzifikace protokolu CALGB 8811 vysokodávkovaným cytosinarabinosidem a metotrexátem. Trans Hemat dnes 2002; 8: 4–12.

12. Houot R, Tavernier E, Le QH, et al. Philadelphia chromosome-positive acute lymphoblastic leukemia in the elderly: prognostic factors and treatment outcome. Hematology 2004, 9: 369–376.

13. Kantarjian HM, O’Brien S, Smith TL, et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 2000; 18(3): 547–561.

14. Shtivelman E, Gale RP, Dreazen O, et al. Bcr-Abl RNA in patients with chronic myelogenous leukemia. Blood 1987; 69: 971–973.

15. Trka J, Zuna J, Haškovec C, et al. Detekce BCR/ABL, MLL/AF4 a TEL/AML1 hybridních genů a monitorování minimální zbytkové nemoci u pediatrických pacientů s akutní lymfoblastickou leukemií. Čas lék česk 1999; 138: 12–17.

16. Cimino G, Pane F, Elia L, et al. The role of BCR/ABL isoforms in the presentation and outcome of patients with Philadelphia-positive acute lymphoblastic leukemia: a seven-year update of the GIMEMA 0496 trial. Haematologica/Hematol J 2006; 91: 377–380.

17. Avivi I, Goldstone AH. Bone marrow transplant in Ph+ ALL patients. Bone Marrow Transplant 2003; 31(8): 623–632.

18. Attal M, Blaise D, Marit G, et al. Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. Blood 1995; 86: 1619–1628.

19. Dunlop LC, Powels R, Singhal S, et al. Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant 1996; 17: 365–369.

20. Cornelissen JJ, Carston M, Kollman C, et al. Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome. Blood 2001; 97(6): 1572–1577.

21. Camera A, Annino L, Chiurazzi F, et al. GIMEMA ALL – rescue 97: a salvage strategy for primary refractory or relapsed adult acute lymphoblastic leukemia. Haematologica 2004; 89: 145–153.

22. Kröger N, Krüger W, Wacker-Backhaus G, et al. Intensified conditioning regimen in bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant 1998; 22: 1029–1033.

23. Doney K, Buckner CD, Fisher L, et al. Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant 1993; 12: 315–321.

24. Wiesdorf DJ, Billett AL, Hannan P, et al. Autologous versus unrelated allogeneic marrow transplantation for acute lymphoblastic leukemia. Blood 1997; 90: 2962–2968.

25. Powels R, Mehta J, Singhal S, et al. Autologous bone marrow or peripheral blood stem cell transplantation followed by maintenance chemotherapy for adult acute lymphoblastic leukemia in first remission: 50 cases from a single center. Bone Marrow transplant 1995; 16: 241–247.

26. Martin H, Atta J, Klein SA, et al. Autologous BMT/PBSCT in 40 patients with Bcr-Abl positive acute lymphoblastic leukemia: long-term follow-up of a GMALL study. Hematol J 2001; I: 187.

27. Ribera J-M, Oriol A, Bethencourt C, et al. Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high-risk acute lymphoblastic leukemia. Results of the PETHEMA ALL-93 trial. Haematologica 2005; 90: 1346–1353.

28. Druker BJ, Sawyers CL, Kantarjian HM, et al. Activity of a specific inhibitor of the BCR–ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001; 344: 1038–1042.

29. Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002; 100: 1965–1971.

30. Pfeifer H, Ottmann O, Goekbuget N, et al. A randomized phase II study of a single-agent imatinib versus chemotherapy in elderly patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) including analysis of resistance patterns. Blood 2005; 106(11): Abstract# 1824.

31. Vignetti M, Fazi P, Meloni G, et al. Dramatic improvement in CR rate and CR duration with imatinib in adult and elderly Ph+ ALL patients: results of the GIMEMA prospective study LAL0201. Blood 2004; 104: Abstract# 2739.

32. Wassmann B, Pfeifer H, Scheuring U, et al. Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Leukemia 2002; 16: 2358–2365.

33. Lee S, Kim YJ, Min CK, et al. The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2005; 105(9): 3449–3457.

34. Delanoy A, Delabesse E, Lheritier V, et al. Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study. Leukemia 2006; 20(9): 1526–1532.

35. Yanada M, Takeuchi J, Sugiura I, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia. Blood 2005; 106(11): Abstract# 1827.

36. Thomas DA, Faderl S, Cortes J, et al. Outcome with the hyper-CVAD and imatinib mesylate regimen in Philadelphia (Ph) positive acute lymphocytic leukemia (ALL). Blood 2005; 106(11): Abstract# 1830.

37. Patel B, Goldstone AH, Ross P, et al. The impact of imatinib therapy on adult Philadelphia positive acute lymphoblastic leukemia (ALL): early results from the UKALL12/ECOG 2993 study. Blood 2005; 106(11): Abstract# 1839.

38. de Labarthe A, Rousselot P, Huguet-Rigal F, et al. Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study. Blood 2007; 109(4): 1408–1413.

39. Hofmann WK, Komor M, Hoelzer D, Ottmann OG. Mechanisms of resistance to STI571 (imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia. Leuk Lymphoma 2004; 45: 655–660.

40. Radich J, Gehly G, Lee A, Avery R, et al. Detection of Bcr-Abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation. Blood 1997; 89(7): 2602–2609.

41. Wassmann B, Pfeifer H, Stadler M, et al. Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 2005; 106(2): 458–463.

42. Keil F, Kalhs P, Haas OA, et al. Relapse of Philadelphia chromosome positive acute lymphoblastic leukemia after marrow transplantation: sustained molecular remission after early and dose-escalating infusion of donor leucocytes. Br J Haematol 1997; 97: 161–164.

43. Scheuring UJ, Pfeifer H, Wassmann B, et al. Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl-positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571). Blood 2003; 101: 85–90.

44. Ottmann OG, Gökbuget N, Wassmann B, Hoelzer D. An open phase II-study to determine the safety and efficacy of imatinib (STI571) in conjunction with induction chemotherapy in patients with newly diagnosed Ph+/BCR-ABL+ acute lymphoblastic leukemia (Ph+ ALL) or with minimal residual disease (MRD) after stem cell transplantation. Protocol GMALL-STI571/MRD-01/01. Amendment 3, version 01.02.2005

45. Visani G, Martinelli G, Piccaluga P, et al. Alpha-interferon improves survival and remission duration in P-190BCR-ABL positive adult acute lymphoblastic leukemia. Leukemia 2000; 14: 22–27.

46. Visani G, Isidori A, Malagola M, et al. Efficacy of imatinib mesylate (STI571) in conjunction with alpha-interferon: long-term quantitative molecular remission in relapsed p190 BCR-ABL positive acute lymphoblastic leukemia. Leukemia 2002; 16: 2159–2160.

47. Wassmann B, Scheuring U, Pfeifer H, et al. Efficacy and safety of imatinib mesylate (Glivec) in combination with interferon-alpha (IFN-alpha) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). Leukemia 2003;17(10):1919–1924.

48. Pfeifer H, Wassmann B, Hofmann WK, et al. Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. Clin Cancer Res 2003; 9(13): 4674–4681.

49. Talpaz M, Shah NP, Kantarjian HM, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354: 2531–2541.

50. Kantarjian HM, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354: 2542–2551.

51. Hoover RR, Mahon FX, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood 2002; 100: 1068–1071.

52. Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. Phosphatidylinositol-3 kinase inhibitor enhance the anti-leukemia effect of STI571. Oncogene 2002; 21: 5868–5876.

53. Giles F, Cortes J, Jones D, et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2006, First Edition Paper, DOI 10.1182/blood-2006-05-025049.