#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Diagnosis and Treatment of Childhood Mature B-acute Lymphoblastic Leukaemia inthe Czech Republic in 1990 –2000


Authors: J. Starý 1;  P. Gajdoš 2;  O. Hrušák 3;  D. Pospíšilová 4;  J. Hak 5;  L. Kopečná 6;  K. Michalová 7
Authors‘ workplace: II. dětská klinika UK 2. LF a FN Motol, Praha, 2 Státní zdravotní ústav, Praha, 3 Imunologický ústav UK 2. LF a FN Motol, Praha, 4 Dětská klinika FN Olomouc, 5 Dětská klinika FN Hradec Králové, 6 I. dětská interní a onkologická klinika FN Brno, 7 Centrum 1
Published in: Transfuze Hematol. dnes,, 2002, No. 2, p. 55-58.
Category:

Overview

Acute lymphoblastic leukaemia (ALL)derived from mature B-cells is in fact generalized Burkitt ´slymphoma.Leukemic blasts are classified as L3 according to the FAB morphological classification.Theyare characterized by the presence of the surface immunoglobulins,most often IgM,and by a highproliferative rate.Current treatment comprising short blocks of intensive chemotherapy improvedremarkably the prognosis of this rare disease.Between VI/1990-XII/2000,ALL was diagnosed in 671children and adolescents aged 0 –18 years in the Czech Republic.B-ALL was found in 9 children (1.3 %).Complete remission was achieved in 77.8 %children.Four patients (44.4 %)suffered from early renalfailure which developed as a result of the tumour lysis syndrome.Neither death in remission nor relapsewere seen in this small group of patients.With a median follow-up of 3,7 years,the probability ofevent-free-survival is 75 %(SE 15 %).Therapeutic results of B-ALLin the Czech Republic are comparableto the results of the leading leukaemic study groups in the world.

Key words:
acute lymphoblastic leukaemia,mature-B-cells,treatment,children

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Haematology Internal medicine Clinical oncology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#