The fourth generation of folates and preconception care
Authors:
Tomáš Fait
Authors‘ workplace:
Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha
Published in:
Prakt Gyn 2014; 18(4): 246-250
Category:
Gynecology and Obstetrics
Overview
The tendency of reproduction delay leads to a higher rate of planned conception. This allows preconception intervention. The importance of folate administration is well documented. Folates reduce the incidence of neural tube defects, congenital heart defects, congenital anomalies of urinary tract, foetuses with lower birth weight, placental pathology and spontaneous abortion. Seventeen German professional societies recommend folate supplementation for at least one month before pregnancy and in the first trimester. Methylfolate [(6S) -5methyltetrahydrofolic acid] is the biologically active folate which is not dependent on the activity of MTHFR. Recently, glucosamine salt of methylfolate (folate of 4th generation) has been introduced and is characterized by greater stability, solubility and bioavalability in comparison to known calcium salts (folate of 3rd generation).
Key words:
folic acid – Quatrefolic® – pregnancy – congenital developmental defects
Sources
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Practical Gynecology
2014 Issue 4
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