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Amniocenthesis: safe invazive method in prenatal diagnostics


Authors: MUDr. Karel Čutka;  MUDr. David Čutka;  MUDr. Milada Šustrová
Authors‘ workplace: Centrum lékařské genetiky, České Budějovice
Published in: Prakt Gyn 2007; 11(1): 23-25

Overview

The article shows an overview of development of amniocenthesis rate (AC) as a basic invazive method in prenatal diagnostics. Czech Rep. in y. 2005 16,5% AC, while 17% of pregnant women underwent some invazive method of prenatal diagnostics. Detection of Down syndrome in Czech Rep. in y. 2005 was 76%, (70% in 1999-2005). Center of Human Genetics (CLG) y. 2005 19% AC while 100% of Down sy was detected (in years 1999-2005 detection 91%). Comparison of abortion rate in female population with AC and overall abortion occurence (AB) in female population in 2nd trimester. The risks do not vary – the AB risk in a group of patients with AC in Center of Human Genetics is not enhanced. The abortion of fetuses is usually caused by dysfunction of placenta, thrombophile mutations or navelwort complication (therefore no relation to performance of AC) To a significant reduction of the number of amniocentheses in population may lead the serum integrated test which is recommended as the best test in areas where measurement of NT by accredited sonographer is not available. Integrated test (completion of measurement of NT by accredited sonographer to biochemical markers of the first and second trimester) is the best screening test with highest detection rate and the lowest false pozitive rate, however, it is accessible to a small part of the population.

Key words:
amniocenthesis - spontaneous abortion- no enhanced risk – detection of Down syndrom – serum integrated test – integrated test


Sources

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Topics Journals
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