#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Treatment of Hepatocellular Carcinoma and Current Situation in the Czech Republic


Authors: M. Oliverius;  F. Bělina *;  J. Novotný **;  P. Studeník ***;  J. Pudil *;  M. Ryska *
Authors‘ workplace: Klinika transplantační chirurgie IKEM, Praha, přednosta: prof. MUDr. M. Adamec, CSc. ;  Chirurgická klinika 2. LF UK a ÚVN, Praha, přednosta: prof. MUDr. M. Ryska, CSc. *;  Komplexní onkologické centrum, Praha, přednosta: doc. L. Petruželka, CSc. **;  Centrum kardiovaskulární a transplantační chirurgie, Brno, ředitel: prof. MUDr. J. Černý, DrSc. ***
Published in: Rozhl. Chir., 2007, roč. 86, č. 12, s. 635-641.
Category: Monothematic special - Original

Overview

Hepatocelullar carcinoma (HCC) is the commonest primary liver malignacy. Its incidence is increasing worldwide. In the Czech Republic, about 250 new cases are reported per year. The patient’s prognosis depends on early diagnosis and initiation of a correct therapeutical procedure. During the decision making process, tumor staging, as well as the chronic liver disease stage, must be considered. Surgery, i.e. liver resection or transplantation, is the only potentially curable method. Other treatment options include chemoembolization, radiofrequency ablation, alcoholization and, currently poorly effective systemic chemotherapy.

Current monitoring of the radical procedures in the Czech Republic is unsatisfactory. Although surgical treatment has been performed by many clinics, based on the available data, none of the following could be assessed: the number of surgically managed HCC patients in the Czech Republic per year, disease staging in these patients and their short-term and long-term treatment outcomes.

In the Czech Republic, 45 liver transplantations have been performed, data on resection procedures are not available.

The aim of the authors is to support the Central HCC Patient Registry, presented at the following website: www.koc.cz.

Key words:
hepatocellular carcinoma – liver resection – liver transplantation – Milano criteria – National Patient Registry


Sources

1. Majno, P., Mentha, G., Giostra, E. Treatment of hepatocellular carcinoma at the dawn of the third millennium: liver transplantation and its alternatives. Acta gastroenterol. Belg., 2004, 67: 206–222.

2. Pawlik, T. M., Scoggins, Ch., Thomas, M. B. Advances in the Surgical Management of Liver Malignancies. Cancer J., 2004, 10: 74–87.

3. Ryder, S. D. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut, 2003, 52: 1–8.

4. Yu, A. S., Keeffe, E. B. Management of Hepatocellular Carcinoma. Rev. Gastroenterol. Disord., 2003, 3(1): 8–24.

5. Tsukuma, H., Hiyami, T., Tanaka, S. Risk factors for hepatocelular carcinoma among patients with chronic liver disease. N. Engl. J. Med., 1993, 328: 1797–1801.

6. Yang, Q., Mc Donnell, S. M., Khoury, M. J. Haemochromatosis-associated mortality in the United States from 1979 to 1992: an analysis of Multiple-Cause Mortality Data. Ann. Intern. Med., 1998, 129: 946–953.

7. Miyakawa, H., Izumi, N., Maruno, F. Roles of alkohol, hepatitis viruses infection and gender in the development of hepatocellular carcinoma in patients with liver cirrhosis. Alcohol. Clin. Exp. Res., 1996, 20: 91–94A.

8. Barbara, L., Benzi, G., Gaiani, S. Natural history of small untreated hepatocellular carcinoma in cirrhosis: a multivariate analysis of prognostic factors of tumor growth rate and patient surfoval. Hepatology, 1992, 16: 132–137.

9. Třeška, V., Skalický, T., Valenta, J., et al. Chirurgická léčba HCC – zkušenosti chirurgické kliniky v Plzni. Bull HPB 2001; 9: 88–89.

10. Král, V., Neoral, Č., Havlík, R. HCC a jeho léčba – názor a zkušenosti klinického pracoviště. Bull HPB 2001; 9: 90–92.

11. Bělina, F. Resekce jater pro HCC – zkušenosti chirurgické kliniky IKEM. Bull HPB 2001; 9: 93–95.

12. Šnajdauf, J., Rygl, M., Petrů, O., et al. Primární karcinom jater v dětském věku. Bull HPB 2001; 9: 82–84.

13. Terminology of nodular hepatocellular lesions. International Working Party. Hepatology, 1995, 17: 27–35.

14. Schwartz, M. Liver Transplantation for Hepatocellular Carcinoma. Gastroenterology, 2004, 127: S268–S276

15. Burand, F., Regimbeaud, J. M., Belghiti, J. Assesment of the benefits and risks of percutaneous biopsy before surgical resection of hepatocellular carcinoma. J. Hepatol., 2001, 35: 254–258.

16. Takamori, R., Wong, L. L., Dang, C, et al. Needle tract implantation from hepaíocellular cancenls needle biopsy of the liver always necessary? Liver Transpl., 2000, 6: 67–72.

17. Okuda, K. Early recognition of hepatocellular carcinoma. Hepatology, 1986, 6: 729–738.

18. Okuda, K., Ohtsuki, T., Obata, H. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer,1985, 56: 918–928.

19. American Joint Committee on Cancer. Manual for staging of cancer. Philadelphia: J. B. Lippincott, 1998, 3: 87–92.

20. United Network for Organ Sharing. Liver transplant candidates with hepatocellular carcinoma (HCC) Policy 3.6.4.4.2002

21. The Cancer of the Liver Italian Program (CLIP) Ivestigators. A new prognostic systém for hepatocellular carcinoma:a retrospective study of 435 patients. Hepatology, 1998, 28: 751–755.

22. Llovet, J. M., Bru, C., Bruix, J. Prognosis of hepatocellular carcinoma:the BCLC staging clasification. Semin. Liver. Dis., 1999, 19: 329–338.

23. Bruix, J., Sherman, M., Llovet, J. M. Clinical Management of hepatocellular carcinoma. Conclusion of the Barcelona – 2000 EASL conference. European Association for the Study of the Liver. J. Hepatol., 2001, 35: 421–430.

24. Jaeck, D., Bacheilier, P., Oussoultzoglou, E. Surgical Resection of Hepatocellular Carcinoma. Post-operative Outcome and Long-term Results in Europe: An Overview. Liver Transpl., 2004, 10: S58–S63.

25. Llovet, J. M., Bruix, J., Gores, G. J. Surgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategy. Hepatology, 2003, 31: 1019–1021.

26. Hasegawa, K., Kokudo, N., Imamura, L., et al. Prognostic impact of anatomic resection for HCC. Ann. Surg., 2005, 242(2): 252–259.

27. Fong, Y., Sun, R. L., Jarnagin, W., et al. An analysis of 412 Cases of Hepatocellular Carcinoma at a Western Center. Ann. Surg., 1999, 229(6): 790.

28. Mazzaferro, V., Regalia, E., Doci, R., et al. Liver transplantation for íhe treaírnent of snnall hepatocellular carcinomas in patients with cirrhosis. N. Engl. J. Med., 1996, 334(11): 693–699.

29. Yao, F. Y., Ferrell, L., Bass, N. M. Liver Transplantation for Hepatocellular Carcinoma: Expansion the Tumor Size Limits Does Not Adversely Impact Survival. Hepatology, 2001, 33: 1394–1403.

30. Todo, S., Furukawa, H. Living Donor Liver Transplantation for Adult Patients With Hepatocellular Carcinoma. Ann. Surg., 2004, 240(3): 451–461.

31. Llovet, J. M. Hepatocellular carcinoma. Lancet, 2003, 362: 1907–1917.

32. Llovet, J. M. Update treatment approach tu hepatocellular carcinoma. J. Gastroenterol., 2005, 40(2): 225–235.

33. Mazzaferro, V., Battiston, C., Perrone, S. Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cinrhotic Patients Awaiting Liver Transplantation. Ann. Surg., 2004, 240(5): 900–909.

Labels
Surgery Orthopaedics Trauma surgery
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#