#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hyaluronic acid and its importance and possibilities of use in otorhinolaryngology


Authors: M. Jurovčík 1;  K. Novotná 1,2;  J. Borský 1;  P. Dytrych 1;  K. Kotaška 1;  Z. Čada 1
Authors‘ workplace: Klinika ušní, nosní a krční 2. LF UK a FN v Motole, Praha 1;  Klinika plastické chirurgie FN Královské Vinohrady, Praha 2
Published in: Otorinolaryngol Foniatr, 72, 2023, No. 4, pp. 204-209.
Category: Review Article
doi: https://doi.org/10.48095/ccorl2023204

Overview

Hyaluronic acid (HA) is a linear, naturally occurring polysaccharide of high molecular weight. It is part of a number of bio logical processes, especially regulatory, anti-inflammatory, immunosuppressive or antiproliferative. It significantly binds water and participates in the maintenance of tissue viscoelasticity, in the supramolecular spatial arrangement of proteoglycans in the extracellular matrix and in the regulation of osmotic pressure, which significantly affects tissue homogeneity and its homeostatic integrity. Due to these properties, non-immunogenic HA can be used in many clinical applications. In otorhinolaryngology, the possibilities of its use are wide, especially in otology, laryngology, rhinology or in the treatment of inflammatory conditions and keloid scars. Some potential areas of use are still in the experimental stage (gene therapy).

Keywords:

Otorhinolaryngology – treatment – hyaluronic acid


Sources

1. Kotaška J, Trč T. Kyselina hyaluronová – charakteristika, její význam a klinické aplikace. Ortopedie 2018; 5: 221–225.

2. Laurent C, Tengblad A, Engström-Laurent A. Hyaluronic acid in secretory otitis media. A bio chemical study of mucoid middle-ear effusions and serum. J Laryngol Otol 1986; 100 (2): 135–140.

3. Torretta S, Marchisio P, Rinaldi V et al. Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. Int J Immunopathol Pharmacol. 2016; 29 (3): 438–442. Doi: 10.1177/0394632016656012.

4. Cioffi L, Gallo P, D‘Avino A et al. Clinical Improvement of Subacute and Chronic Otitis Media With Effusion Treated With Hyaluronic Acid Plus Hypertonic Solution via Nasal Lavage: A Randomized Controlled Trial. Glob Pediatr Health 2017; 4: 2333794X17725983. Doi: 10.1177/2333794X17725983.

5. Kotaška K, Hanousková L, Průša R et al. Hyaluronic acid concentration in the middle ear fluid as an indicator of severity of the secretory otitis in newborns with cleft palate. Acta Biochim Pol 2021; 68 (4): 795–797. Doi: 10.18388/abp.2020_5672.

6. Jurovčík M, Borský J, Dytrych P et al. První příznaky sekretorické otitidy u novorozenců ope rovaných pro rozštěpovou vadu – záchyt v desetiletém souboru. Otorinolaryngol Foniatr 2020; 69 (2): 55–61.

7. Topazio D, Passali FM, Cama A et al. Intranasal hyaluronic acid improves the audiological outcomes of children with otitis media with effusion. Indian J Otol 2019; 25: 1155–1161.

8. Lehnhardt E. Intracochlear electrode placement facilitated by Healon. Adv Otorhinolaryngol 1993; 48: 62–64. Doi: 10.1159/000422559.

9. Sidell D, Ward JA, Pordal A et al. Combination therapies using an intratympanic polymer gel delivery system in the guinea pig animal model: A safety study. Int J Pediatr Otorhinolaryngol 2016; 84: 132–136. Doi: 10.1016/j.ijporl.2016. 03.002.

10. Ramos BF, Tsuji RK, Bento RF et al. Hearing preservation using topical dexamethasone alone and associated with hyaluronic acid in cochlear implantation. Acta Otolaryngol 2015; 135 (5): 473–477. Doi: 10.3109/00016489.2014.995831.

11. Kabelka Z, Boleslavská V, Lesný P et al. Chirurgické komplikace v souboru 206 dětských uživatelů kochleárního implantátu. Otorinola ryn gol Foniatr 2005; 54 (2): 71–75.

12. Abi Zeid Daou C, Bassim M. Hyaluronic acid in otology: Its uses, advantages and drawbacks – A review. Am J Otolaryngol 2020; 41 (2): 102375. Doi: 10.1016/j.amjoto.2019.102375.

13. Angeli SI. Hyaluronate gel stapedotomy. Otolaryngol Head Neck Surg 2006; 134 (2): 225–231. Doi: 10.1016/j.otohns.2005.09.028.

14. Laurent C, Hellstrom S, Fellenius E. Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties. Arch Otolaryngol Head Neck Surg 1988; 114 (12): 1435–1441. Doi: 10.1001/archotol.1988. 01860240085029.

15. Hellstrom S, Laurent C. Hyaluronan and healing of tympanic membrane perforations. An experimental study. Acta Otolaryngol Suppl 1987; 442: 54–61. Doi: 10.3109/00016488709102840.

16. Saliba I, Woods O. Hyaluronic acid fat graft myringoplasty: a minimally invasive technique. Laryngoscope 2011; 121 (2): 375–380. Doi: 10.1002/lary.21365.

17. Saliba I, Froehlich P. Hyaluronic acid fat graft myringoplasty: an office-based technique adapted to children. Arch Otolaryngol Head Neck Surg 2011; 137 (12): 1203–1209. Doi: 10.1001/ archoto.2011.188.

18. Zhang H, Wei YT, Tsang KS et al. Implantation of neural stem cells embedded in hyal uronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model. J Transl Med 2008; 6: 67. Doi: 10.1186/1479-5876-6-67.

19. Mancini R, Khadavi NM, Goldberg RA. Nonsurgical management of upper eyelid margin asymmetry using hyaluronic acid gel filler. Ophthalmic Plast Reconstr Surg 2011; 27 (1): 1–3. Doi: 10.1097/IOP.0b013e3181c2a16d.

20. Aarnisalo A, Aarnisalo P, Pietola Let al. Efficacy of Gene Transfer through the Round Window Membrane: An in vitro Model. ORL 2006; 68: 220–227. Doi: 10.1159/000092123.

21. Shibata SB, Cortez SR, Wiler JA et al. Hyal uronic acid enhances gene delivery into the cochlea. Hum Gene Ther 2012; 23 (3): 302–310. Doi: 10.1089/hum.2011.086.

22. Gouveris H, Selivanova O, Mann W. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy. Eur Arch Otorhinolaryngol 2005; 262 (2): 131–134. Doi: 10.1007/s00405-004-0772-6.

23. Sha SH. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001; 155 (1–2): 1–8. Doi: 10.1016/s0378-5955 (01) 00224-6.

24. Selivanova OA, Gouveris H, Victor A et al. Intratympanic dexamethasone and hyaluro nic acid in patients with low-frequency and Meniere‘s-associated sudden sensorineural hearing loss. Otol Neurotol 2005; 26 (5): 890–895. Doi: 10.1097/01.mao.0000185050.69394.48.

25. Naples JG, Henry L, Brant JA et al. Intratympanic Therapies in Meniere Disease: Evaluation of Outcomes and Early Vertigo Control. Laryngoscope 2019; 129 (1): 216–221. Doi: 10.1002/lary.27392.

26. Torretta S, Marchisio P, Rinaldi V et al. Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. Eur Arch Otorhinolaryngol 2017; 274 (3): 1423–1429. Doi: 10.1007/s00405-016-4327-4.

27. Jang CH, Cho YB, Choi CH et al. Effect of anti-adhesion barrier solution containing ciprofloxacin-hydrocortisone on abraded mucosa with otitis media. Int J Pediatr Otorhinolaryngol 2013; 77 (1): 19–24. Doi: 10.1016/j.ijporl.2012.09.018.

28. Hayashi NN. The effect of hyaluronic acid on the growth of cholesteatoma, Oto-Rhino-Laryngology Tokyo 1991; 34 (6): 489–501.

29. White SJ, Wright CG, Robinson KS et al. Effect of topical hyaluronic acid on experimental cholesteatoma. Am J Otolaryngol 1995; 16 (5): 312–318. Doi: 10.1016/0196-0709 (95) 90059-4.

30. Martini A, Morra B, Aimoni C, Radice M. Use of a hyaluronan-based bio membrane in the treatment of chronic cholesteatomatous otitis media. Am J Otol 2000; 21 (4): 468–473.

31. Casale M, Vella P, Moffa A et al. Hyaluro nic acid and upper airway inflammation in pediatric population: A systematic review. Int J Pediatr Otorhinolaryngol 2016; 85: 22–26. Doi: 10.1016/j.ijporl.2016.03.015.

32. Ialenti A, Di Rosa M. Hyaluronic acid modulates acute and chronic inflammation. Agents Actions 1994; 43 (1–2): 44–47. Doi: 10.1007/BF02005763.

33. Varricchio A, Capasso M, Avvisati F et al. Inhaled hyaluronic acid as ancillary treatment in children with bacterial acute rhinopharyngitis. J Biol Regul Homeost Agents 2014; 28 (3): 537–543.

34. Macchi A, Castelnuovo P, Terranova P et al. Effects of sodium hyaluronate in children with recurrent upper respiratory tract infections: results of a randomised controlled study. Int J Immunopathol Pharmacol 2013; 26 (1): 127–135. Doi: 10.1177/039463201302600112.

35. Casale M, Pace A, Moffa A et al. Post-operative nebulized sodium hyaluronate versus spray after functional endoscopic sinus surgery for chronic rhinosinusitis. J Biol Regul Homeost Agents 2017; 31 (4 Suppl 2): 81–89.

36. Dal T, Bahar S. The clinical outcomes of using a new cross-linked hyaluronan gel in endoscopic frontal sinus surgery. Eur Arch Otorhinolaryngol 2017; 274 (9): 3397–3402. Doi: 10.1007/s00405-017-4638-0.

37. Wang CC, Chang MH. A proposal to extend application of laryngeal electromyography (LEMG) -guided vocal fold injection to treatment of unilateral vocal fold paralysis to enhance clinical popularity of LEMG: response to the paper by G. F. Volk et al. Eur Arch Otorhinolaryngol 2013; 270 (4): 1563–1565. Doi: 10.1007/s00405-012-2211-4.

38. Hertegård S, Hallén L, Laurent C et al. Cross-linked hyaluronan used as augmentation substance for treatment of glottal insufficiency: safety aspects and vocal fold function. Laryngoscope 2002; 112 (12): 2211–2219. Doi: 10.1097/00005537-200212000-00016.

39. Olmos-Zuniga JR, Baltazares-Lipp M, Hernandez-Jimenez C et al. Treatment with Hyal uronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. Biomed Res Int 2020; 2020: 3964518. Doi: 10.1155/2020/ 3964518.

40. Tammi R, Ripellino JA, Margolis RU et al. Hyaluronate accumulation in human epidermis treated with retinoic acid in skin organ culture. J Invest Dermatol 1989; 92 (3): 326–332. Doi: 10.1111/1523-1747.ep12277125.

41. DI Stadio A. Ear Keloid Treated with Infiltrated Non-cross-linked Hyaluronic Acid and Cortisone Therapy. In Vivo 2016; 30 (5): 695–699.

42. Sobec RL, Fodor L, Bodog F. Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. Plast Reconstr Surg 2019; 143 (2): 481-487. Doi: 10.1097/PRS.0000000000005275.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)

Article was published in

Otorhinolaryngology and Phoniatrics

Issue 4

2023 Issue 4

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#