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An Unusual Form of Fibroproduction Induced in the Rat Lung by Intratracheal Instillation of Some LittleFibrogenic Dusts


Authors: Holuša Radim . 1 2;  Škoda Václav 1
Authors‘ workplace: Krajská hygienická stanice Ostrava, ředitel MUDr. Jaroslav Volf 2 Státní zdravotní ústav Praha, ředitel doc. MUDr. Jaroslav KřížCentrum hygieny práce a nemocí z povolání, vedoucí prof. MUDr. Miroslav Cikrt, DrSc.
Published in: Pracov. Lék., , 1999, No. 4, s. 154-159.
Category:

Overview

In the course of testing of fibrogenicity of industrial dust samples in rats, an unusual morphological type of the formation ofstrong collagen bundles of collagen fibres in coniophagic foci induced by a series of five instilled dust of low or mediumfibrogenicity, expressed by the determination of collagen multiplication in the lungs. Four dust samples represented various formsof aluminium oxide (gamma Al2O3, corundum, resistex/SiO2 .Al2O3/, starting dust for the production of artificial corundum) and the fifth sample is from diorite. The findings arediscussed in view of evaluating the results of intratracheal test and its improvement, particularly by the use of histopathologicalevaluation of the induced changes

Key words:
industrial dust - intratracheal test - corundum - gamma AL2O3 - resistex - diorite - collagen - Saturn red

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Hygiene and epidemiology Hyperbaric medicine Occupational medicine
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