Influence of Anticholinergic Drug Selection on the Efficacy in Antidote Therapy of Cholinergic and Stressogenic Effects ofSoman in the Rat

Czech version

Authors: J. Kassa
Authors‘ workplace: Vojenská lékařská akademie JEP, Hradec Královérektor doc. MUDr. Svatopluk Býma, CSc.
Published in: Pracov. Lék., , 1999, No. 2, s. 54-58.
Category:

Overview

The experiments in male rats investigated the influence of selected anticholinergic drugs (atropin, benactyzin, biperiden) on theeffect of a new asymmetric bisquarternary oxime BI-6 against cholinergic and stressogenic effects of the highly toxic organophos-phate soman. The soman-induced inhibition of acetylcholinesterase in blood, diaphragm or CNS, as well as the soman-inducedhypercorticosteronemia and increased activity of tyrosine aminotransferase in liver, were markedly more influenced by oxime BI-6in combination with benactyzin or biperidine than in combination with atropin.The results obtained appear to indicate that benactyzin or biperiden are anticholinergic drugs which represent therapeuticadvantage over the so far used atropin, if the poisoning is treated with oxime BI-6.

Key words:
soman, BI-6, benactyzin, biperiden, acetylcholineesterase, corticosterone, tyrosine aminotransferase, rat

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Article was published in

Occupational Medicine

1999 Issue 2