#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Drug induced lung toxicity by nitrofurantoin


Authors: Samuel Genzor;  Vítězslav Kolek;  Monika Žurková;  Milan Sova
Authors‘ workplace: Klinika plicních nemocí a tuberkulózy LF UP a FN Olomouc
Published in: Čas. Lék. čes. 2020; 159: 35-37
Category: Case Report

Overview

We present the clinical case of the patient with nitrofurantoin (FUR) lung toxicity. Diagnosis was made from detailed history of the patient and by studying CT images before the start of FUR treatment. An extensive interstitial changes were evident on HRCT scan at the presentation at our clinic. The definitive diagnosis was supported by negative microbiology and autoantibody screening and almost complete regression of changes after FUR treatment withdrawal. There was no need for corticosteroid treatment or immunosuppressive medication.

Keywords:

treatment – nitrofurantoin – drug induced lung toxicity


Sources

1. Camus P. Pneumotox Online. The Drug-Induced Respiratory Disease Website. Dostupné na: www.pneumotox.com

2. Holmberg L, Boman G, Bottiger LE et al. Adverse reactions to nitrofurantoin – Analysis of 921 reports. Am J Med 1980; 69: 733–738.

3. Guvenir H, Arikoglu T, Vezir E, Misirlioglu ED. clinical phenotypes of severe cutaneous drug hypersensitivity reactions. Curr Pharm Des 2019; 25(36) :3840–3854.

4. Jörg L, Yerly D, Helbling A, Pichler W. The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome. Allergy 2019 Dec 9, doi: 10.1111/all.14146.

5. Roden AC, Camus P. Iatrogenic pulmonary lesions. Semin Diagn Pathol 2018; 35(4): 260–271.

6. Claussen K, Stocks E, Bhat D et al. How common are pulmonary and hepatic adverse effects in older adults prescribed nitrofurantoin? J Am Geriatr Soc 2017; 65(6): 1316–1320.

7. Lošťáková V, Kuna M, Kolek V et al. Polékové postižení plic. Klinická farmakologie a farmacie 2018: 32(4): 21–31.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#