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Regulatory Network of Transcription Factors: Their Key Role in the Development and Function of Pancreas


Authors: P. Lukášová;  J. Včelák;  M. Vaňková;  D. Vejražková;  B. Bendlová
Authors‘ workplace: Endokrinologický ústav, Praha
Published in: Čas. Lék. čes. 2007; 146: 227-234
Category: Review Article

Overview

Recent molecular biological studies of the pancreatic development have shed new light on the cause of MODY and diabetes mellitus type 2. The identification of transcription factors participating in the regulatory networks cooperating in the development and in adult exocrine and endocrine pancreas enabled the better understanding of the genetic background and subsequent phenotypic features of diabetes.

Key words:
transcription factor, pancreas, mutation, polymorphism, MODY, diabetes mellitus type 2, insulin.


Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians


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