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Changes of Plasminogen Activator Inhibitor (PAI-1) During Estrogen Replacement Therapy


Authors: Z. Žižka;  Tomáš Fait;  M. Vráblík 1
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha ;  III. interní klinika 1. LF UK a VFN, Praha 1
Published in: Čas. Lék. čes. 2007; 146: 874-877
Category: Original Article

Overview

Background.
The purpose of the present study was to determine changes of plasminogen activator inhibitor – 1 (PAI-1) as biochemical cardiovascular risk factor during the use of different administration methods in the early estrogen replacement therapy. 

Methods and Results.
In a 12-week prospective, randomized, interventional, cross-over trial, oestradiol was administered orally in a dose of 2 mg daily or transdermally in a dose of 0.05 mg daily. Forty-five healthy postmenopausal women were included into the study within 12 weeks after the hysterectomy and ovariectomy (surgical castration). Forty-one women completed the study and their data were analyzed. The average age was of 49±6 years. PAI-1 was determined by bioimmunoassay (ChromolyzeTM PAI-1). The PAI-1 level decreased statistically significantly (p = 0.001) after the oral oestrogen therapy from 11.39±12.02 IU/l to 5.0±5.27 IU/l. Changes are also significant compared with non-significant changes after the transdermal therapy. 

Conclusions.
The oral therapy reduced statistically significantly PAI-1 levels compared with the transdermal method of administration. This change is beneficial from the view of cardiovascular risk. 

Key words:
Estrogen replacement therapy, cardiovascular risk, PAI-1.


Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Article was published in

Journal of Czech Physicians

Issue 11

2007 Issue 11

Most read in this issue
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