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Regulation of Receptor Function in the Central Nervous System


Authors: J. Mysliveček;  S. Trojan
Authors‘ workplace: Fyziologický ústav 1. LF UK, Praha
Published in: Čas. Lék. čes. 2003; : 340-350
Category:

Overview

The basic condition of life is capability to adapt not only to external but also to internal milieu conditions. I.e.receptors are able to change the intensity of signal transduction from the extracellular to the intracellular compartmentin a short period. In a specific manner it concerns all receptor structures, both if they are located in cytoplasm orwithin the membrane. This review concentrates to the mechanisms existing in G protein-coupled receptors. Thoseprotein structures can undergo a homologous or heterologous regulation. Homologous regulation means that onlythe properties of a receptor system influenced via extracellular signalling are changed. Heterologous regulationmeans, that receptor properties are changed despite that the extracellular signalling did not influence the receptor.It is possible to consider such changes as one of the level o homeostasis. Both homologous and heterologousregulations are essential for many physiological and pathophysiological processes. The most important examples ofthese processes, especially in the central nervous system, are reviewed here.

Key words:
G protein-coupled receptors, homologous regulation, heterologous regulation, phosphorylation, CNSreceptor malfunction.

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