Transitive Elements and Free Radicals
Authors:
J. Racek; J. Eiselt 1; K. Opatrný jr. 1
Authors‘ workplace:
Ústav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzeň 1) 1. interní klinika LF UK a FN, Plzeň
Published in:
Čas. Lék. čes. 2002; : 479-482
Category:
Overview
Iron and copper are essential trace elements, which in certain conditions, namely in the ionised form or inlow-molecular complexes, can participate in single electron reactions and catalyse formation of free radicals,including the dangerous hydroxyl radical. Similar behavior have also some other transitive metals. Our overview isaimed on the role of transitive elements in the formation of free radicals and on the mechanisms that organisms haveto prevent it. The highest attendance is given to the metabolism of iron and cooper. Consistent protection againstfree transitive metals (by binding with proteins, by oxidation or sequestration in a special compartment) enablesorganism to use their beneficial and required features without impairment of cell. Knowledge of these mechanismsprovides the means to predict and effectively prevent the brake down of such defend systems in situations of theintravascular hemolysis, hemodialysis, administration of iron, impairments of the iron and copper metabolism,intoxication by oxidising substances etc.
Key words:
transitive metals, copper, iron, free radicals, Fenton’s reaction.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
Most read in this issue
- Significance of Assessing of Serological Markers in Patients with CeliacDisease
- Transitive Elements and Free Radicals
- Exercise Cardiorespiratory Indexes in ChildrenMotivated to Physical Activity After Treatment for Acute Lymphoblastic Leukemia
- Interventional Methods in the Treatment of Malignant Tumors of the Liver