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Modern Therapy of Hematological Malignancies


Authors: M. Trněný
Authors‘ workplace: I. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2001; : 711-716
Category:

Overview

Remarkable progress has been done during the last three decades in the therapy of hematological malignancies.It is now possible to cure significant number of patients by chemotherapy, radiotherapy, and stem cell transplantation.However, there is still a large group of patients and situations where our approaches are failing. It is evident that insome circumstance chemotherapy and radiotherapy get close to their limits. A short insight into the group of noveltherapeutic methods is given in this review. Such promising methods of treatment include the new chemotherapeuticdrugs, new molecules that specifically act on the level molecular mechanisms (STI 571, ATRA, arsenic trioxide,etc.), immunotherapy (monoclonal antibodies, vaccination strategy, exploration of dendritic cells etc.), gene therapyand innovations in stem cell transplantation (graft versus leukemia/lymphoma effect). The future treatment willinclude combination of standard or intensified chemo/radiotherapy and the new methods, which allow better controlof the disease.

Key words:
leukemia, lymphoma, myeloma, immunotherapy, monoclonal antibodies, chemotherapy, radiothera-py, gene therapy, transplantation.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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