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Multiple Extrarenal Complications of Wegener’s Granulomatosis - A Case Report


Authors: Z. Říhová;  M. Merta;  R. Ryšavá;  P. Bezdíček;  V. Danzig;  K. Goričan;  J. Lukáš;  P. Skalická;  Z. Vernerová;  V. Tesař
Authors‘ workplace: I. interní klinika 1. LF UK a VFN, Praha IV. interní klinika 1. LF UK a VFN, Praha ORL oddělení VFN, Praha Oční klinika 1. LF UK a VFN, Praha Ústav patologie 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2001; : 503-505
Category:

Overview

This is a case report of a patient with Wegener’s granulomatosis (WG), who initially presented with a corneal perforation. In addition to the eye involvement, the pauciimmune necrotizing glomerulonephritis with crescent formation, E.N.T. and pulmonary involvement were diagnosed. The patient also suffered from the acute myocardial infarction, most likely due to coronal arteritis. In addition to the coronal ischeamia she also had vasculitis of the aortic valve due to the WG. Another rare complication was the massive intestinal bleeding. The patient had also a skin vasculitis and non-specific symptoms such as artralgias and fever. The correct diagnosis was supported by positive cANCA. A clinical and laboratory remission of the disease was achieved by combined immunosuppressive therapy. Subsequently, she developed a subglotic stenosis possibly due to reparative changes.

Key words:
Wegener’s granulomatosis, ANCA, aortic valvulitis, subglottic stenosis.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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