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Concentration of Circulating Advanced Glycation end Products of in the Model of Acute Renal insufficiency in Rats


Authors: P. Boor;  P. Božek;  P. Blažíček;  D. Syrová;  R. Schinzel;  A. Heidland;  A. Pecovová;  K. Šebeková
Authors‘ workplace: Lekárska fakulta Univerzity Komenského, Bratislava Nemocnica ministerstva vnútra SR, Bratislava Nemocnica Ministerstva obrany SR, Bratislava Inštitút fyziologickej chémie I, Biocentrum, Wuerzburg, SRN Interná klinika Univerzity Wuerzburg, SRN Ústav preven
Published in: Čas. Lék. čes. 2001; : 375-380
Category:

Overview

Background.
Advanced glycation end products (AGEs) are formed from proteins and peptides by non-enzymatic glycation or glycoxidation. AGEs are formed slowly during aging, and they accumulate in circulation and tissues in diabetes and chronic renal failure. Kidney plays a key role in the disposal of AGEs. Aim of this study was to verify the hypothesis that, acute loss of renal function with enhanced oxidative and carbonyl stress should results in a rise of circulating AGEs levels.Method and Results. Acute renal failure (ARI) was induced in rats by bilateral nephrectomy (24-72 hours). The data on AGEs levels, oxidative status and antioxidative defense was compared to those of sham operated animals. 48 hours after the induction of ARI concentrations of AGEs, determined fluorimetrically or as carboxymethyllysine, rose 2-fold, and they correlated with concentrations of creatinine (r=0.938, p

Key words:
advanced glycation end products, acute renal failure, Ne-carboxymethyllysine, malondialdehyde, lipofuscine, total antioxidant status, oxidative stress, carbonyl stress.

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