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Humoral Profile in Patients with Severe Aortic Stenosis


Authors: J. Hrudová;  A. Linhart;  V. Vondráček;  J. Humhal;  F. Holm;  M. Jáchymová;  J. Ort;  Z. Marečková;  K. Horký
Authors‘ workplace: II. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2000; : 74-78
Category:

Overview

Background.
While the effect of neurohormones is often studied in congestive heart failure, their role in aorticstenosis needs to be elucidated.Methods. 54 consecutive patients with symptomatic aortic stenosis without overt heart failure were studied at theage of 64.4±9.3 yrs with echocardiography, x-ray and catheterization. Levels of circulating atrial natriuretic factorendothelin-1, catecholamines, plasma renin activity, immunoreactive insulin and C-peptide were assessed, relatedto hemodynamic data and compared to those in 23 healthy controls, aged 59.2±12.8 yrs.Results. Patients had significantly higher plasma levels of endothelin-1 (z-value 0.64±1.19, p=0.019), atrialnatriuretic factor (z-value 2.46±2.46, p

Key words:
aortic stenosis, left ventricular hypertrophy, neurohormones, endothelin-1, pulmonary hypertension

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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