Therapy of Osteoarthrosis - from Influencing the Symptoms to Preservation of the Articular Cartilage
Authors:
K. Pavelka
Authors‘ workplace:
Revmatologický ústav, Praha
Published in:
Čas. Lék. čes. 2000; : 487-493
Category:
Overview
An overview of pharmacological and surgical approaches aiming to preserve the articular cartilage and preventprogression of degeneration during osteoarthrosis (OA) is given. From the pharmacological approaches the mostpromising appears to be glucosaminosulphate from the SYSADOA group. Also preparations affecting the bonemetabolism as calcitonin and biosulphates are tested. Along with it some biological curatives blocking the activityof IL-1, TNF-a, MMP, and NO are experimentally used. They have been parenterally administered, however, thegene therapy enabling transfer of the genetic information by means of retroviruses directly into the joint and synthesisof the target proteins in situ becomes clinically tested. From the surgical approaches aimed to preserve the articularcartilage several methods are currently tested: joint debridment, transplantation of the soft components, transplan-tation of the cartilage grafts and some experimental methods.
Key words:
osteoarthritis, structure modifying treatment, surgical therapy.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
Most read in this issue
- Occurrence of the Reflux Oesophagitis in Patients with Chest Pain andwith Normal Selective Coronary Angiogram
- Clinical Picture of Homocystinuria from the Cystathionine b-synthaseDeficiency in Nineteen Czech and Slovak Patients
- Laser Trabeculoplasty Today
- Therapy of Osteoarthrosis - from Influencing the Symptoms to Preservation of the Articular Cartilage