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Porphyria Cutanea Tarda after Antineoplastic Drugs


Authors: L. Malina;  H. Michalíková;  L. Hussarová 1
Authors‘ workplace: Dermatovenerologická klinika 3. LF UK, Praha 1 Onkologické odd. ÚVN, Praha
Published in: Čas. Lék. čes. 1999; : 536-538
Category:

Overview

Chronic hepatic porphyria is in some cases a paraneoplasia, in others part of the neoplastic disease. Sometimes itis, on the other hand manifested during antineoplastic treatment. Its development may be associated with this therapy.The presented case-history describes a female patient with breast cancer treated with antineoplastic agents, whodeveloped a sporadic form of late cutaneous porphyria with a classical clinical and laboratory picture.The authors contemplate on the possible porphyrinogenic effect of antineoplastic agents, in particular cyclophos-phamide and tamoxifen, which in the latter preparation was not described so far.

Key words:
porphyria, porphyria cutanea tarda, PCT, porphyrogenicity, antineoplastic agents, 5-fluorouracil,cyclophosphamide, tamoxifen.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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