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Role of eplerenone in the threatment of cardiovascular diseases


Authors: Filip Málek
Authors‘ workplace: Kardiovaskulární centrum, Nemocnice Na Homolce, Praha
Published in: Vnitř Lék 2023; 69(E-2): 23-25
Category:
doi: https://doi.org/10.36290/vnl.2023.025

Overview

Eplerenone is a selective mineralocorticoid receptor antagonist. Its approved for the therapy of patients with chronic heart
failure with left ventricular systolic dysfunction and for the patients after myocardial infarction complicated by heart failure
and left ventricular dysfunction. It´s also recommended for the therapy of primary hyperaldosteronism and the treatment of
drug resistant hypertension.

Keywords:

Resistant hypertension – heart failure – eplerenone – mineralocorticoid receptors – hyperaldosteronism


Sources

1. Málek F, Špaček R. Blokáda receptoru aldosteronu v terapii chronického srdečního selhání. Cor Vasa. 2002,44:32-36.

2. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2022;24:4-131.

3. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/ HFSA Guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145:e895-e1032.

4. Pitt B, Remme W, Zannad F, et al. Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction N Engl J Med. 2003;348:1309-21.

5. Zannad F, McMurray JJV, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11-21.

6. Mairgani G, Mále V, Málek F. The importance of a higher dose of a mineralocorticoid receptor antagonist in reducing risk of reccurent hospitalization in a patient with advanced chronic heart failure – a case report. Cor Vasa 2018;60:e527-530.

7. Capuano A, Scavone C, Vitale C, et al. Mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction (HFpEF). Int J Cardiol. 2015,200:15-19.

8. Widimský J, Filipovský J, Ceral J, et al. Diagnostické a léčebné postupy u arteriální hypertenze. Doporučení České společnosti pro hypertenzi. Hypertenze α kardiovaskulární prevence Suppl. 2022;12(2):1-25.

9. SPC Eplerenon. Available from: file:///C:/Users/11366/Downloads/eplerenon‑sandoz‑spc% 20(1).pdf.

Labels
Diabetology Endocrinology Internal medicine
Topics Journals
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