Acute infections in kidney transplant recipients

Czech version

Authors: Zdeněk Lys ^1,3; Klára Dombrovská ¹; Jarmila Dědochová ¹; Petra Kovářová ²; Ivo Valkovský ^1,3; Jan Václavík ^1,3
Authors‘ workplace: Interní a kardiologická klinika, FN Ostrava ¹; Krevní centrum, FN Ostrava ²; Lékařská fakulta, Ostravská univerzita ³
Published in: Vnitř Lék 2022; 68(E-3): 12-17
Category: Review Articles

Overview

Immunosuppressed kidney transplant recipients have a high risk of infectious complications. A variety of infections of viral, bacterial, or mycotic etiology, including opportunistic infections, occur in this group of patients, but bacterial infections are primarily responsible for the high infection-related mortality. Of the bacterial infections, urinary tract infections and pneumonia are the most common, often requiring hospitalization and temporary reduction of immunosuppressive therapy after consultation of the transplant center. In addition to symptoms due to the location of the infection, fever is often present. The differential diagnosis of fever and/or high inflammatory activity is specific to patients after kidney transplantation. In addition to infectious causes, we consider drug-related fever, a rejection episode, a relapse of systemic disease or in patients with graft failure in dialysis treatment graft intolerance syndrome (“symptomatic graft”). Saving the patient’s life, which often requires a significant reduction in immunosuppressive therapy, always takes precedence over preventing a rejection episode. Infection prevention is an integral part of the care of transplant patients, including the recommendation of vaccination where possible.

Keywords:

kidney transplantation – immunosuppression – antibiotics – rejection – acute infection

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Internal Medicine

2022 Issue E-3