Selected severe „haematological“ syndromes in adult intensive care patients

Czech version

Authors: Jaromír Gumulec ^1,4; Ivo Demel ¹; Klára Lančová ¹; Eva Drbohlavová ²; Alicia Piegzová ³; Zdeněk Kořístek ^1,4; Milan Navrátil ^1,4; Vladimír Černý ⁵
Authors‘ workplace: Klinika hematoonkologie Fakultní nemocnice Ostrava ¹; Klinická hematologie Krajské nemocnice Liberec, a. s. ²; Gynekologicko‑porodnická, klinika Fakultní nemocnice Ostrava ³; Lékařská fakulta Ostravské univerzity ⁴; Klinika anesteziologie, perioperační a intenzivní medicíny Fakulty zdravotnických studií Univerzity J. E. Purkyně, v Ústí nad Labem a Krajské zdravotní, a. s. – Masarykovy nemocnice v Ústí nad Labem, o. z. ⁵
Published in: Vnitř Lék 2022; 68(8): 498-507
Category: Main Topic
doi: https://doi.org/10.36290/vnl.2022.107

Overview

Haemophagocytic syndrome, diffuse alveolar haemorrhage, catastrophic antiphospholipid syndrome and various types of thrombotic microangiopathies are rare conditions with significant morbidity and mortality. A common feature is late diagnosis, which can affect the success of treatment. The aim of this review article is to summarize the basic diagnostic and therapeutic steps of the present subpopulation of critically ill patients.

Keywords:

vasculitis – thrombotic thrombocytopenic purpura – thrombotic microangiopathy – plasma exchange – thrombosis – immunosuppressive therapy – diffuse alveolar haemorrhage – rituximab – eculizumab – hemophagocytic lymphohistiocytosis – antiphospholipid syndrome – hemophagocytic syndrome – HLH – macrophage activation syndrome – cytokine storm syndrome – catastrophic antiphospholipid syndrome – haemolytic‑uremic syndrome – etoposide – recombinant factor VIIa – caplacizumab – ravulizumab

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Další literatura u autorů a na www.casopisvnitrnilekarstvi.cz