Non-celiac gluten sensitivity

Czech version

Authors: Iva Hoffmanová ¹; Daniel Sánchez ²
Authors‘ workplace: II. interní klinika 3. LF UK a FN Královské Vinohrady Praha, přednosta prof. MUDr. Michal Anděl, CSc. ¹; Laboratoř buněčné a molekulární imunologie Mikrobiologického ústavu AV ČR, v. v. i., Praha, ředitel RNDr. Martin Bilej, CSc. ²
Published in: Vnitř Lék 2015; 61(3): 219-227
Category: Review

Overview

Non-celiac gluten sensitivity has recently been recognized by the scientific community as a part of gluten-related disorders, and is defined as a condition with gastrointestinal and/or extra-intestinal symptoms triggered by gluten ingestion in the absence of celiac disease and wheat allergy. Currently, there is no specific serological marker and non-celiac gluten sensitivity remains a diagnosis of exclusion: testing for celiac disease and wheat allergy must be negative, symptoms must improve with a gluten-free diet, and diagnosis must be confirmed by the gluten challenge. In this article, we discuss current knowledge of pathophysiology, clinical and epidemilogical spectrum, diagnosis, and treatment of NCGS.

Keywords:
celiac disease – FODMAPs – gluten-free diet – gluten-related disorders – irritable bowel syndrome – non-celiac gluten sensitivity – wheat allergy

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