SIADH as only paraneoplastic cause of the small cell lung cancer: case report
Authors:
P. Lokaj; L. Křivan
Authors‘ workplace:
Interní kardiologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC
Published in:
Vnitř Lék 2008; 54(3): 273-275
Category:
Case Reports
Overview
62 years old patient was admitted to the hospital with weakness of lower extremities. Using laboratory examination, we found very severe hyponatrenaemia, hypochloraemia and hypotonia of blood plasma, because of SIADH. We searched for the cause of that syndrome and finally we found that the cause of that syndrome was small cell lung cancer with an expansion into the mediastinum and metastases into the skelet.
Keywords:
syndrome of inappropriate antidiuretic hormone secretion - small cell lung cancer
Sources
1. Adam Z, Vorlíček J, Kostíková J. Obecná onkologie a podpůrná léčba. Praha: Grada Publishing 2003; 587- 591.
2. Dítě P et al. Vnitřní lékařství. Brno: Masarykova univerzita 2005: vol. 3.
3. Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med 2000; 342: 1581-1589.
4. Bednařík J et al. Učebnice speciální neurologie. Brno 1999; 133-134.
5. Schuck O Poruchy metabolismu vody a elektrolytů v klinické praxi. Praha: Grada Publishing 2000; 59-62.
6. Griva M, Kubánek J Syndrom nepřiměřené sekrece antidiuretického hormonu u nediferencovaného malobuněčného karcinomu plic. Vnitř Lék 2002; 48: 993-995.
7. Seute T, Leffers P, ten Velde GP et al. Neurologic disorders in 432 consecutive patients with small cell lung carcinoma. Cancer 2004; 100; 801-806.
8. Mussig K, Horger M, Haring HU et al. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in pacients with limited stage small cell lung cancer. Lung Cancer 2007; 57; 120-122.
9. Rafailov A, Sinert R Syndrome of Inappropriate Antidiuretic Hormone Secretion. E-Medicine 2007, Endocrine and Metabolic
10. Rai A, Whaley-Connell A, McFarlane S et al. Hyponatremia, arginine vasopressin dysregulation, and vasopressin receptor antagonism. Am J Nephrol 2006; 26: 579-589.
11. Verbalis JG AVP receptor antagonists as aquaretics: review and assessment of clinical data. Cleve Clin J Med 2006; 73: Suppl. 3: S24-S33.
12. Sorensen JB, Andersen MK, Hansen HH Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Int Med 1995; 238: 97-110.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
![Issue 3](https://www.prolekare.cz/media/cache/resolve/journal_issue/media/image_pdf/a5fbc78c260ffbb3935f50411a81e99a.jpeg)
2008 Issue 3
Most read in this issue
- Idiopathic retroperitoneal fibrosis - Ormond’s disease
- Von Willebrand disease
- SIADH as only paraneoplastic cause of the small cell lung cancer: case report
- Treatment of IgA nephropathy