Tuberculosis in old age
Authors:
M. Vlachová
Authors‘ workplace:
Geriatrická klinika 1. LF UK a VFN Praha
Published in:
Geriatrie a Gerontologie 2015, 4, č. 1: 26-30
Category:
Review Article
Overview
Tuberculosis (TB) is second only to HIV/AIDS as the greatest infectious disease killer worldwide despite its decreasing incidence. Elderly population is the largest reservoir of TB in developed countries, which was primarily infected before era of vaccination, antitubeculous drugs and existence of resistent types of Mycobacterium tuberculosis. Polymorbid frail residents of long term care facilities are in greatest risk for reactivation of latent TB. Diagnostics and treatment are difficult in old age due to frequent atypical clinical signs and adverse reactions of antituberculous drugs. Therefore post mortem diagnosis is very often. Considering tuberculosis in the differential diagnosis remains the cornerstone of a fast and accurate diagnosis and treatment of this condition.
Keywords:
tuberculosis – latent tuberculosis – old age – long term care facility
Sources
1. Tuberculosis: Fact sheet N°104. World Health Organisation [online]. [cit. 2015-01-15]. Dostupné z: http://www.who.int/mediacentre/factsheets/fs104/en/
2. Výskyt tuberkulózy v České republice v roce 2013. ÚZIS [online]. [cit. 2015-01-15]. Dostupné z: http://www.uzis.cz/rychle-informace/vyskyt-tuberkulozy-ceske-republice-roce-2013
3. Yoshikawa TT. Tuberculosis in aging adults. Journal of the American Geriatric Society 1992; 40(2): 178–187.
4. Van der Brande P. Revised guidelines for the diagnosis and control of tuberculosis: impact on management in the elderly. Drugs Aging 2005; 22(8): s. 663–686.
5. Stead WW. Tuberculosis among elderly persons: an outbreak in a nursing home. Ann Intern Med 1981; 94(5): 606–610.
6. Tuberkulóza dospělých – standard léčebného plánu. Česká pneumologická a ftizeologická společnost [online]. [cit. 2015-01-15]. Dostupné z: http://www.pneumologie.cz/guidelines/?potvrzeni1=1&potvrzeni2=1&potvrdit=ANO%0D%0AVstoupit#
7. Pérez-Guzmán C. Does aging modify pulmonary tuberculosis? A meta-analytical review. Chest 1999; 116(4): 961–967.
8. Morris CD. The haematological and biochemical changes in severe pulmonary tuberculosis. Q J Med 1989; 73(12): 1151–1159.
9. Tuberculin Skin Testing. CDC [online]. [cit. 2015-01-15]. Dostupné z: http://www.cdc.gov/tb/publications/factsheets/testing/skintesting.htm
10. Interferon-Gamma Release Assays (IGRAs) – Blood Tests for TB Infection. CDC [online]. [cit. 2015-01-15]. Dostupné z: http://www.cdc.gov/tb/publications/factsheets/testing/igra.htm
11. Packham S. Tuberculosis in the elderly. Gerontology 2001; 47(4): 175–179.
12. Stead WW, et al. Benefit-risk considerations in preventive treatment for tuberculosis in elderly persons. Ann Intern Med 1987; 107(6): 843–845.
13. Bothamley GH. Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey. Eur Respir J 2008; 32(4): 1023–1030.
14. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005. CDC [online]. 2005 [cit. 2015-01-19]. Dostupné z: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5417a1.htm?s_cid=rr5417a1_e
15. Criteria for discontinuation of vaccination programmes using Bacille Calmette-Guerin (BCG) in countries with a low prevalence of tuberculosis. A statement of the International Union Against Tuberculosis and Lung Disease. Tuber Lung Dis 1994; 75(3): 179–180.
16. Metodika pravidelného očkování proti tuberkulóze. Česká pneumologická a fteziologická společnost [online]. 2013 [cit. 2015-01-20]. Dostupné z: http://www.pneumologie.cz/guidelines/.
17. Jerab J, et al. Tuberculosis contact investigations: outcomes in selected areas of the United States, 1999. Int J Tuberc Lung Dis 2003; 12(Suppl 3): 384–390.
18. Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC. CDC [online]. 2012 [cit. 2015-01-20]. Dostupné z: http://www.cdc.gov/tb/publications/guidelines/contactinvestigations.htm
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Geriatrics General practitioner for adults Orthopaedic prostheticsArticle was published in
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