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Respiratory epithelial adenomatoid hamartoma of the nasal cavity: A case report of a rare lesion of the sinonasal region


Authors: V. Bartoš 1;  P. Rác 2;  A. Skálová 3
Authors‘ workplace: Martinské bioptické centrum, s. r. o., Martin Odborný garant: prof. MUDr. Lukáš Plank, CSc. 1;  Nemocnica s poliklinikou, Považská Bystrica Otorinolaryngologická ambulancia Lékař: MUDr. Peter Rác 2;  Bioptická laboratoř, s. r. o., Plzeň Odborná vedoucí lékařka: prof. MUDr. Alena Skálová, CSc. 3
Published in: Prakt. Lék. 2024; 104(4): 207-211
Category: Case Report

Overview

Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign lesion originating from the mucosal epithelium of the nasal cavity and paranasal sinuses. We describe a 51-year-old man with a history of persistent difficulty breathing and feeling of stuffy nose. He was diagnosed to have a large polypoid mass in the right nasal cavity with a stalk arising from the olfactory cleft. Grossly, it was a compact polyp measuring 40 × 32 × 10 mm with a smooth surface. The histology confirmed the diagnosis of REAH with predominance of glandular structures with a transition to seromucinous hamartoma. After the operation, the clinical problems had disappeared and the patient was free of recurrence. Despite rare occurrence, REAH should be included in the differential diagnosis of sinonasal polypoid masses, especially of those which originate from the posterior part of the nasal septum or olfactory cleft. Early recognition and correct diagnosis prevent unnecessary aggressive surgery and other burdensome examinations.

Keywords:

nasal polyps – respiratory epithelial adenomatoid hamartoma – sinonasal masses


Sources
  1. Baněčková M, Michal M, Laco J, et al. Immunohistochemical and genetic analysis of respiratory epithelial adenomatoid hamartomas and seromucinous hamartomas: are they precursor lesions to sinonasal low-grade tubulopapillary adenocarcinomas? Hum Pathol. 2020; 97: 94–102.
  2. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. (Eds.) WHO classification of head and neck tumours (4th edition). Lyon: IARC 2017.
  3. Fitzhugh VA, Mirani N. Respiratory epithelial adenomatoid hamartoma: a review. Head Neck Pathol. 2008; 2(3): 203 –208.
  4. Jechová A, Balatková Z, Plzák J. Respirační epitelový adenomatoidní hamartom typická, ale poddiagnostikovaná patologie dutiny nosní a vedlejších dutin nosních. Čas. Lék. čes. 2019; 158(6): 253–255.
  5. Kumari S, Pandey S, Verma M, et al. Clinicopathological challenges in tumors of the nasal cavity and paranasal sinuses: Our experience. Cureus 2022; 14(9): e29128.
  6. Krtičková J, Laco J, Dědková J, a kol. Respirační epiteliální adenomatoidní hamartom. Otorinolaryng a Foniat. (Prague) 2019; 68(4): 211–216.
  7. Mujeeb AA, Singavarapu PR, Chaganti LA, et al. Respiratory epithelial adenomatoid hamartoma in a young female: A diagnostic dilemma. Cureus 2023; 15(10): e46453.
  8. Nefzaoui S, Zoghlami I, Gharsalli J, et al. Respiratory epithelial adenomatoid hamartoma: A rare differential diagnosis of sinonasal mass. Rare Tumors 2024; 16: 20363613241255567.
  9. Rom D, Lee M, Chandraratnam E, et al. Respiratory epithelial adenomatoid hamartoma: An important differential of sinonasal masses. Cureus 2018; 10(4): e2495.
  10. Sudheer Kumar M, Bishnoi T, Sahu PK et al. An inflammatory polyp-like benign sinonasal mass lesion – respiratory epithelial adenomatoid hamartoma: A case report. Indian J Otolaryngol Head Neck Surg. 2023; 75(4): 3999–4022.

adresa pre korešpondenciu:
MUDr. PhDr. Vladimír Bartoš, PhD., MPH
Martinské bioptické centrum, s.r.o.
Prieložtek 1, 036 01 Martin, SR
e-mail:
vladim.bartos@gmail.com

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