Bradykinin-induced angioedema and its differential diagnosis
Authors:
P. Králíčková 1; E. Malá 1; P. Rozsíval 2; Jana Krtičková 3; I. Krčmová 1
Authors‘ workplace:
Univerzita Karlova v Praze, Lékařská fakulta a Fakultní nemocnice Hradec Králové
; Ústav klinické imunologie a alergologie, Přednosta: prof. RNDr. Jan Krejsek, CSc.
1; Dětská klinika, Přednosta: prof. MUDr. Milan Bayer, CSc.
2; Klinika otorinolaryngologie a chirurgie hlavy a krku, Přednosta: prof. MUDr. Viktor Chrobok, Ph. D.
3
Published in:
Prakt. Lék. 2012; 92(7): 378-382
Category:
Reviews
Overview
A significant proportion of population has experience with angioedema. According to the pathophysiology it is possible to subdivide angioedema into histamine- or bradykinin induced. They fundamentally differ from each other in aetiology, clinical picture and management. This article is focused on bradykinin-induced angioedema, comprising: hereditary angioedema, ACE-inhibitors induced-angioedema and acquired angioedema. These diagnoses are often neglected. Inadequate treatment could lead to a patient’s death. C1 inhibitor substitution and bradykinin-receptor blocker play key roles in the management of the condition. Corticosteroids, antihistamines or adrenalin are ineffective in such cases.
Key words:
angioedema, bradykinin, hereditary, C1 inhibitor, icatibant
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General Practitioner
2012 Issue 7
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