#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Uncertainties in the Diagnosis of Liver Cirrhosis


Authors: E. Černý
Authors‘ workplace: I. patologickoanatomický ústav LF MU, Brno, přednosta prof. MUDr. A. Rejthar, CSc.
Published in: Prakt. Lék. 2003; (8): 454-456
Category:

Overview

Liver cirrhosis is not yet uniformly defined even from morphological aspects, although there isagreement in basic tissue changes involved. The conflicting features include particularly theso-called regeneration nodes and a prognosis-related favourable transformation of micro-nodulesin macro-nodules. The nodulation visible by eye remains a doubtful feature in diagnosis.Thecases of cirrhosis with a smooth surface escape clinical diagnosis. The diagnosis should betherefore based on the previously acknowledged pseudolobulus, a histologically typical islandof parenchyma (at least two in the biopsy preparation) considering the possibility that it maybe connected with parenchyma outside the plane of cut (according to net structure of nodule-likereconstructed liver). The basic architectonics of the liver is not yet fully recognized, sincea unicellular muralium appears to be one of extreme structures, less frequent than bi-cellulartrabeculae according to our experience; the organization of hepatocytes in a mixture of unicellularand bi-cellular plates appear to be commonly present. For the evaluation of regenerationof hepatocytes in cirrhosis the findings of Ki-67, PCNA, etc. appear to be more reliable thanhistological criteria.

Key words:
liver - cirrhosis - morphological - development - diagnostic criteria

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
General practitioner for children and adolescents General practitioner for adults
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#