Methotrexate is the re-discovered drug for Crohn’s disease

Czech version

Authors: M. Lukáš
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty, Klinické centrum ISCARE a. s. a 1. LF UK v Praze
Published in: Gastroent Hepatol 2024; 78(1): 37-40
Category: IBD
doi: https://doi.org/10.48096/ccgh202437

Overview

Methotrexate, the analog of folic acid, was introduced for clinical practice more than 60 years ago being utilized for immune-mediated disorders including also Crohn’s disease. In the difference from rheumatoid arthritis patients, methotrexate in Crohn’s disease patients is used in higher dosages and preferable route of administration is parenteral (subcutaneous) application. Indication for methotrexate therapy is a mild to moderate severity of Crohn’s disease after induction the remission due to topic or systemic corticosteroids therapy. Other indication for methotrexate therapy is concomitant immunosuppressive therapy with anti-TNF drugs. The cotemporary application of methotrexate is associated with higher trough level of infliximab and in less frequent of anti-drugs antibody production. Comparing to thiopurins, methotrexate therapy is associated with lower risk of severe side effects and there is no contraindication to start therapy in those patients with a history of malignancy.

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ORCID autora

M. Lukáš 0000-0002-1463-3840.

Doručeno/ Submitted: 5. 2. 2024
Přijato/ Accepted: 12. 2. 2024

prof. MU Dr. Milan Lukáš, CSc., AGAF
Klinické a výzkumné centrum pro střevní záněty
Klinické centrum ISCARE a.s. a 1. LF UK v Praze
Českomoravská 19
190 00 Praha 9
milan.lukas@email.cz