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Obesity in children and kidney diseases


Authors: Marinov Z. 1;  Marinová C. 2
Authors‘ workplace: Dětská obezitologická ambulance FN Motol, Praha 1;  Medasol s. r. o., Praha 2
Published in: Gastroent Hepatol 2019; 73(6): 509-516
Category:
doi: https://doi.org/10.14735/amgh2019509

Overview

Chronic kidney disease and non-alcoholic fatty liver disease are global public health concerns. Diabetes, hypertension, and obesity are risk factors for and major contributors to these diseases. Common obesity is frequent in developed countries and is accompanied by chronic metabolic changes. Adipose tissue is the largest endocrine organ in the body, and expansion of this organ results in gradual but extensive cardiometabolic changes due to insulin resistance, proinflammatory status, and endothelial dysfunction, with irreversible central dysregulation of energy homeostasis. The renal and liver effects of common obesity may have their origins in childhood overweight.

Conflict of Interest: The authors declare that the article/manuscript complies with ethical standards, patient anonymity has been respected, and they state that they have no financial, advisory or other commercial interests in relation to the subject matter.

Publication Ethics: This article/manuscript has not been published or is currently being submitted for another review.

The authors agree to publish their name and e-mail in the published article/manuscript.

Dedication: The article/manuscript is not supported by a grant nor has it been created with the support of any company.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted: 2. 12. 2019

Accepted: 5. 12. 2019

Keywords:

children obesity – cardiometabolic risk – programming – non-alcoholic fatty liver disease


Sources

1. Procházka B, Kratěnová J, Žejglicová K et al. Aktuální výskyt rizikových faktorů ischemické choroby srdeční u dětí v ČR v roce 2016. Čes-slov Pediat 2018; 73 (8): 501–508.

2. Iqbal U, Perumpail BJ, Akhtar D et al. The epidemiology, risk profiling and diagnostic challenges of nonalcoholic fatty liver disease. Medicines (Basel) 2019; 6 (1): E41. doi: 10.3390/medicines6010041.

3. de Jong PE, Verhave JC, Pinto-Sietsma SJ et al. Obesity and target organ damage: the kidney. Int J Obes Relat Metab Disord 2002; 26: S21–S24. doi: 10.1038/sj.ijo.0802213

4. Marinov Z, Střítecká H, Riedlová J at al. Programování energetické homeostázy. DMEV 2015; 18 (2): 69–74.

5. Abitbol CL, Chandar J, Rodriguez MM et al. Obesity and preterm birth: additive risks in the progression of kidney disease in children. Pediatr Nephrol 2009; 24 (7): 1363–1370. doi: 10.1007/s00467-009-1120-2.

6. O’Sullivan L, Combes AN, Moritz KM. Epigenetics and developmental programming of adult onset diseases. Pediatr Nephrol 2012; 27 (12): 2175–2182. doi: 10.1007/s00467-012-2108-x.

7. Leontovyčová J, Janda J. Nízká porodní hmotnost a další rizikové faktory pro pozdější onemocnění u dětí a dospělých (prenatální a postnatální programming). Čes-slov Pediat 2018; 73 (3): 166–172.

8. Hanson M, Gluckman P. Developmental origins of noncommunicable disease: population and public health implications. Am J Clin Nutr 2011; 94 (Suppl 6): S1754–S1758. doi: 10.3945/ajcn.110.001206.

9. Plagemann A, Harder T, Rake A et al. Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 1999; 836 (1–2): 146–155. doi: 10.1016/s0006-8993 (99) 01662-5.

10. Kett MM, Denton KM. Renal programming: cause for concern? Am J Physiol Regul Integr Comp Physiol 2011; 300 (4): 791–803. doi: 10.1152/ajpregu.00791.2010.

11. Luyckx VA, Bertram JF, Brenner BM et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet 2013; 382 (9888): 273–283. doi: 10.1016/S0140-6736 (13) 60311-6.

12. Andersen LG, Angquist L, Eriksson JG et al. Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies. PLoS One 2010; 5 (11): e14126. doi: 10.1371/journal.pone.0014126.

13. Lelièvre-Pégorier M, Merlet-Bénichou C. The number of nephrons in the mammalian kidney: environmental influences play a determining role. Exp Nephrol 2000; 8 (2): 63–65. doi: 10.1159/000020649.

14. Boubred F, Saint-Faust M, Buffat C et al. Developmental origins of chronic renal disease: an integrative hypothesis. Int J Nephrol 2013: 346067. doi: 10.1155/2013/346067.

15. Vikse BE, Irgens LM, Leivestad T et al. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008; 19 (1): 151–157. doi: 10.1681/ASN.2007020252.

16. Stene LC, Magnus P, Lie RT et al. Birth weight and childhood onset type 1 diabetes: population based cohort study. BMJ 2001; 322 (7291): 889–892. doi: 10.1136/bmj.322.7291.889.

17. Krishnamurthy J, Torrice C, Ramsey MR et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114 (9): 1299–1307. doi: 10.1172/JCI22475.

18. Agostoni C, Turck D. Is cow’s milk harmful to a child’s health? J Pediatr Gastroenterol Nur 2011; 53 (6): 594–600. doi: 10.1097/MPG.0b013e318235b23e.

19. Escribano J, Luque V, Ferre N et al. Increased protein intake augments kidney volume and function in healthy infants. Kidney Int 2011; 79 (7): 783–790. doi: 10.1038/ki.2010.499.

20. Lobstein T, Jackson-Leach R. Estimated burden of paediatric obesity and co-morbidities in Europe. Part 2. Numbers of children with indicators of obesity-related disease. Int J Pediatr Obes 2006; 1 (1): 33–41. doi: 10.1080/17477160600586689.

21. Srivastava T. Nondiabetic consequences of obesity on kidney. Pediatr Nephrol 2006; 21 (4): 463–470. doi: 10.1007/s00467-006-0027-4.

22. Pantoja-Zuzuárregui JR, Mallios R, Murphy J. The effect of obesity on kidney length in a healthy pediatric population. Pediatr Nephrol 2009; 24 (10): 2023–2027. doi: 10.1007/s00467-009-1202-1.

23. Gunta SS, Mak RH. Is obesity a risk factor for chronic kidney disease in children? Pediatr Nephrol 2013; 28 (10): 1949–1956. doi: 10.1007/s00467-012-2353-z.

24. Daschner M, Tönshoff B, Blum WF et al. Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Am Soc Nephrol 1998; 9 (6): 1074–1079.

25. Mitsnefes M, Kartal J, Khoury P et al. Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. Clin J Am Soc Nephrol 2007; 2 (1): 46–50. doi: 10.2215/CJN.02790806.

26. Yoshinaga M, Sameshima K, Tanaka Y et al. Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children. Circ J 2008; 72 (11): 1874–1878. doi: 10.1253/circj.cj-08-0180.

27. Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol 2008; 159 (Suppl 1): S67–S74. doi: 10.1530/EJE-08-0245.

28. Jolliffe CJ, Janssen I. Vascular risks and management of obesity in children and adolescents. Vasc Health Risk Manag 2006; 2 (2): 171–187. doi: 10.2147/vhrm.2006.2.2.171.

29. Teplan V, Lukáš M, Beňo P et al. Obezita a ledviny. Gastroent Hepatol 2017; 71 (6): 510–516. doi: 10.14735/amgh2017510.

30. Burgert TS, Dziura J, Yeckel C et al. Micro-albuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors. Int J Obes (Lond) 2006; 30 (2): 273–280. doi: 10.1038/sj.ijo.0803136.

31. Verhulst SL, Van Hoeck K, Schrauwen N et al. Sleep-disordered breathing and proteinuria in overweight and obese children and adolescents. Horm Res 2008; 70 (4): 224–229. doi: 10.1159/000151594.

32. Ferris M, Hogan SL, Chin H et al. Obesity, albuminuria, and urinalysis findings in US young adults from the Add Health Wave III Study. Clin J Am Soc Nephrol 2007; 2 (6): 1207–1214. doi: 10.2215/CJN.00540107.

33. Lane PH. Pediatric aspects of diabetic kidney disease. Adv Chronic Kidney Dis 2005; 12 (2): 230–235. doi: 10.1053/j.ackd.2005.01.005.

34. Pinhas-Hamiel O, Dolan LM, Daniels SR et al. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996; 128 (5): 608–615. 10.1016/s0022-3476 (96) 80124-7.

35. Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005; 116 (2): 473–480. 10.1542/peds.2004-2536.

36. Edelstein SL, Knowler WC, Bain RP et al. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 1997; 46 (4): 701–710. doi: 10.2337/diab.46.4.701.

37. Sellers EA, Blydt-Hansen TD, Dean HJ et al. Macroalbuminuria and renal pathology in First Nation youth with type 2 diabetes. Diabetes Care 2009; 32 (5): 786–790. doi: 10.2337/dc08-1828.

38. Muntner P, He J, Cutler JA et al. Trends in blood pressure among children and adolescents. JAMA 2004; 291 (17): 2107–2113. doi: 10.1001/jama.291.17.2107.

39. Sorof J, Daniels S. Obesity hypertension in children: a problem of epidemic proportions. Hypertension 2002; 40 (4): 441–447. doi: 10.1161/01.hyp.0000032940.33466.12.

40. Lee WW. An overview of pediatric obesity. Pediatr Diabetes 2007; 8 (Suppl 9): S76–S87. doi: 10.1111/j.1399-5448.2007.00337.x.

41. Garrison RJ, Kannel WB, Stokes J 3rd et al. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med 1987; 16 (2): 235–251. doi: 10.1016/0091-7435 (87) 90087-9.

42. Falkner B, DeLoach S. Refining the blood pressure phenotype in children: when does target organ damage begin? Hypertension 2009; 53 (6): 905–906. doi: 10.1161/HYPERTENSION AHA.109.130070.

43. Bakris GL, Ritz E. The message for World Kidney Day 2009: hypertension and kidney disease – a marriage that should be prevented. Pediatr Nephrol 2009; 24 (3): 427–430. doi: 10.1007/s00467-008-1112-7.

44. El-Atat FA, Stas SN, McFarlane SI et al. The relationship between hyperinsulinemia, hypertension and progressive renal disease. J Am Soc Nephrol 2004; 15 (11): 2816–2827. doi: 10.1097/01.ASN.0000133698.80390.37.

45. Glowinska B, Urban M, Koput A et al. New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents. Atherosclerosis 2003; 167 (2): 275–286. doi: 10.1016/s0021-9150 (03) 00003-0.

46. Nicklas TA, von Duvillard SP, Berenson GS. Tracking of serum lipids and lipoproteins from childhood to dyslipidemia in adults: the Bogalusa Heart Study. Int J Sports Med 2002; 23 (Suppl 1): S39–S43. doi: 10.1055/s-2002-28460.

47. Friedland O, Nemet D, Gorodnitsky N et al. Obesity and lipid profiles in children and adolescents. J Pediatr Endocrinol Metab 2002; 15 (7): 1011–1016. doi: 10.1515/jpem.2002.15.7. 1011.

48. Webber LS, Harsha DW, Phillips GT et al. Cardiovascular risk factors in Hispanic, white, and black children: the Brooks County and Bogalusa Heart studies. Am J Epidemiol 1991; 133 (7): 704–714. doi: 10.1093/oxfordjournals.aje.a115945.

49. Pacifico L, Bonci E, Andreoli GM et al. The impact of nonalcoholic fatty liver disease on renal function in children with overweight/obesity. Int J Mol Sci 2016; 17 (8). doi: 10.3390/ijms17081218.

50. Feldstein AE, Patton-Ku D, Boutelle KN. Obesity, nutrition, and liver disease in children. Clin Liver Dis 2014; 18 (1): 219–231. doi: 10.1016/j.cld.2013.09.003.

51. Correia-Costa L, Sousa T, Morato M at al. Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function. Br J Nutr 2016; 116: 805–815. doi: 10.1017/S0007114516002804.

52. Meyer AA, Kundt G, Steiner M et al. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 2006; 117 (5): 1560–1567. doi: 10.1542/peds.2005-2140.

53. Giannini C, de Giorgis T, Scarinci A et al. Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children. Atherosclerosis 2008; 197 (1): 448–456. doi: 10.1016/j.atherosclerosis.2007.06. 023.

54. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007; 87 (1): 315–424. doi: 10.1152/physrev.00029.2006.

55. Marinov Z. Nadváha a běžná obezita v dětském věku – zdravotní výzva 21. století. Lékařské listy 2014; 9: 21–24.

56. Ong KK, Ahmed ML, Emmett PM et al. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ 2000; 320 (7240): 967–971. doi: 10.1136/bmj.320.7240.967.

57. Druet C, Stettler N, Sharp S et al. Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis. Paediatr Perinat Epidemiol 2012; 26 (1): 19–26. doi: 10.1111/j.1365-3016.2011.01213.x.

58. Weng SF, Redsell SA, Swift JA et al. Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy. Arch Dis Child 2012; 97 (12): 1019–1026. doi: 10.1136/archdischild-2012-302263.

59. Yim HE, Yoo KH. Early life obesity and chronic kidney disease in later life. Pediatr Nephrol 2015; 30 (8): 1255–1263. doi: 10.1007/s00467-014-2922-4.

60. Marinov Z, Pastucha D. Komplexní metabolické změny u obézních dětí. Pediatr praxi 2012: 13 (1): 12–15.

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Paediatric gastroenterology Gastroenterology and hepatology Surgery

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