Papilárny adenokarcinóm žalúdka

Download PDF English version

Authors: Tkacik M.
Authors‘ workplace: Gastroenterological ambulance, Hospital Polyclinic Brezno, N. O.
Published in: Gastroent Hepatol 2019; 73(5): 404-408
Category:
doi: https://doi.org/10.14735/amgh2019404

Overview

58-ročný pacient bol prijatý do nemocnice pre bolesti brucha, žalúdočný vred a zhoršené hepatálne parametre. Na CT boli zistené mnohopočetné ložiská charakteru metastáz v hepare, početná lymfadenopatia až pakety zväčšených lymfatických uzlín hlavne v oblasti retroperitonea, peripankreaticky a v oblasti distálneho žalúdka, takisto aj ložiská v pľúcach, pravdepodobne metastázy. Histopatologicky sa potvrdil papilárny adenokarcinóm z oblasti vredu žalúdka v prepylorickej oblasti. Vzhľadom k diseminácii ochoreniam bola prognóza nepriaznivá, onkológ neindikoval onkologickú liečbu, pokračovali sme v liečbe v zmysle best supportive care.

Klíčová slova:

včasný tumor žalúdka – lymfadenopatia – pečeňové metastázy – papilárny adenokarcinóm

Sources

1. Jemal A, Bray F, Center MM et al. Global cancer statistics. CA Cancer J Clin 2011; 61 (2): 69–90. doi: 10.3322/caac.20107.

2. Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127 (12): 2893–2917. doi: 10.1002/ijc.25516.

3. Národné centrum zdravotníckych informácií. Incidencia zhubných nádorov v Slovenskej republike 2011. [online]. Dostupné z: http: //www.nczisk.sk/Documents/publikacie/analyticke/incidencia_zhubnych_nadorov_2011.pdf.

4. Hwang SW, Lee DH, Lee SH et al. Preoperative staging of gastric cancer by endoscopic ultrasonography and multidetector-row computed tomography. J Gastroenterol Hepatol 2010; 25 (3): 512–518. doi: 10.1111/j.1440-1746.2009. 06106.x.

5. Polkowski W, van Sandick JW, Offerhaus GJ et al. Prognostic value of Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction. Ann Surg Oncol 1999; 6 (3): 290–297.

6. Lauren P. The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31–49. doi: 10.1111/apm.1965.64.1.31.

7. Caldas C, Carneiro F, Lynch HT et al. Familial gastric cancer: overview and guidelines for management. J Med Genet 1999; 36 (12): 873–880.

8. Kaneko S, Yoshimura T. Time trend analysis of gastric cancer incidence in Japan by histological types, 1975–1989. Br J Cancer 2001; 84 (3): 400–405. doi: 10.1054/bjoc.2000.1602.

9. Parsonnet J, Vandersteen D, Goates J et al. Helicobacter pylori infection in intestinal-and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst 1991; 83 (9): 640–643. doi: 10.1093/jnci/ 83.9.640.

10. Yamada A, Kaise M, Inoshita N et al. Characterization of Helicobacter pylori-Naïve Early Gastric Cancers. Digestion 2018; 98 (2): 127–134. doi: 10.1159/000487795.

11. Lauwers GY, Carneiro F, Graham DY et al. Gastric carcinoma. In: Bosman FT, Carneiro F, Hruban RH et al (eds.). WHO classification of tumours of the digestive system. Lyon: IARC Press 2010: 48–58.

12. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31–49. doi: 10.1111/apm.1965.64.1.31.

13. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3^rd English ed. Gastric Cancer 2011; 14 (2): 101–112. doi: 10.1007/s10120-011-0041-5.

14. Yu H, Fang C, Chen L et al. Worse prognosis in papillary, compared to tubular, early gastric carcinoma. J Cancer 2017; 8 (1): 117–123. doi: 10.7150/jca.17326.

15. Sieberová G. Pohľad a diferenciálna diagnostika patológa. Gastroenterol prax 2011; 10 (2): 75–81.

16. Yasui W, Sentani K, Motoshita J et al. Molecular pathobiology of gastric cancer. Scand J Surg 2006; 95 (4): 225–231. doi: 10.1177/145749690 609500403.

17. Kitaura K, Chone Y, Satake N et al. Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats. Jpn J Cancer Res 1999; 90 (4): 385–392. doi: 10.1111/j.1349-7006.1999.tb007 59.x.

18. Lin X, Zhao Y, Song WM et al. Molecular classification and prediction in gastric cancer. Comput Struct Biotechnol J 2015; 13: 448–458. doi: 10.1016/j.csbj.2015.08.001.

19. Rima FA, Hussain M, Haque N et al. HER2 status in Gastric and Gastroesophageal Junction Adenocarcinoma. Mymensingh Med J 2017; 26 (2): 372–379.

20. Akiyama T, Sudo C, Ogawara H et al. The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science 1986; 232 (4758): 1644–1646.

21. Popescu NC, King CR, Kraus MH. Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32. Genomics 1989; 4 (3): 362–366.

22. Oono Y, Kuwata T, Takashima K et al. Clinicopathological features and endoscopic findings of HER2-positive gastric cancer. Surg Endosc 2018; 32 (9): 3964–3971. doi: 10.1007/ s00464-018-6138-8.

23. Uesugi N, Sugai T, Sugimoto R et al. Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma. Pathology 2017; 49 (6): 596–603. doi: 10.1016/j.pathol.2017.07.004.

24. Hamilton R, Aatonen LA (eds). Tumors of the digestive system. Lyon: IARC 2000: 39–52.

25. Everett SM, Axon AT. Early gastric cancer in Europe. Gut 1997; 41 (2): 142–150. doi: 10.1136/gut.41.2.142.

26. Yoshikawa K, Maruyama K. Characteristics of gastric cancer invading to the proper muscle layer – with special reference to mortality and cause of death. Jpn J Clin Oncol 1985; 15 (3): 499–503.

27. Yasuda K, Adachi Y, Shiraishi N et al. Papillary adenocarcinoma of the stomach. Gastric Cancer 2000; 3 (1): 33–38.

28. Huang Q, Zou X. Clinicopathology of early gastric carcinoma: an update for pathologists and gastroenterologists. Gastrointest Tumors 2017; 3 (3–4): 115–124. doi: 10.1159/000456005.

29. Hattori T, Sentani K, Hattori Y et al. Pure invasive micropapillary carcinoma of the esophagogastric junction with lymph nodes and liver metastasis. Pathol Int 2016; 66 (10): 583–586. doi: 10.1111/pin.12450.

30. Huang Q, Fang C, Shi J et al. Differences in clinicopathology of early gastric carcinoma between proximal and distal location in 438 Chinese patients. Scientific Report 2015; 5: 13439. doi: 10.1038/srep13439.

31. Koseki K, Takizawa T, Koike M et al. Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 2000; 89 (4): 724–732.

32. Gertler R, Stein HJ, Schuster T et al. Prevalence and topography of lymph node metastases in early esophageal and gastric cancer. Ann Surg 2014; 259 (1): 96–101. doi: 10.1097/ SLA.0000000000000239.